Results 131 to 140 of about 952,123 (344)
, 2014 The cleaned and dried foot bone rings like porcelain when tapped. Michelle Lee, Diana Mellon and Yijun Wang, 2014. © Making and Knowing Project (CC BY-NC-SA)
The Making and Knowing Project
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Editorial: Epistemic Feelings: Phenomenology, Implementation, and Role in Cognition
Frontiers in Psychology, 2020 Eric Dietrich +3 more
doaj +1 more source
KNOWING E SENSEMANKING: CONSTRUÇÃO DE SENTIDO E RENOVAÇÃO DO CONHECIMENTO NO ENSINO À DISTÂNCIA
Revista Gestão Universitária na América Latina, 2017 Knowledge and its acquisition, creation and development have awakened the attention of researchers and organizations once there is a knowledge dependence of the individuals that act in the organization.
Nilson Varella Rübenich +2 more
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Skill Building in the Lab Seminars
, 2017 Pamela Smith describes a range of skill building exercises that train students in laboratory work, reconstruction, and experiment design in the Making and Knowing Project’s Craft and Science course. Director Lan Li, 2017. © Making and Knowing Project (CC
The Making and Knowing Project
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Project Theme: Practical Knowledge
, 2017 Pamela Smith discusses some of the insights gained in 2016-17, when the Making and Knowing Project focused on Practical knowledge, including vernacular natural history, practical perspective, optics, mechanics, and medicine.
The Making and Knowing Project
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