Results 131 to 140 of about 2,678,948 (305)
Unpacking Knowing Integration: A Practice-based Study in Haute Cuisine [PDF]
Within a practice-based approach of organizations, we explore the knowing integration phenomena at the roots of competitive advantage. While former knowing integration studies have pointed to the importance of boundary objects across occupational ...
Bouty, Isabelle, Gomez, Marie-Léandre
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Dini Araştırmalar, 2015 The purpose of this study is to determine how individuals define the concepts of knowing/ knowledge and believing/belief. Another purpose was to explore the subjects understanding of presented knowledge or belief self discovered knowledge or belief For ...
Öznur Özdoğan +1 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Sosyal Bilimler Felsefesi Açısından Bil(in)mek ve Kur’an
Eskiyeni, 2013 İnsanoğlu çevresiyle farklı şekil ve düzeylerde ilişkiler kurar. Bu yazıda bu ilişkilerden “tanıma ve bilme” adı verilen ilişki sosyal bilimler felsefesi açısından ele alınacaktır.
Murat Kayacan
doaj
Journal of Awareness-Based Systems ChangeThis issue's In-Dialogue represents the intentional epitomization of many conversations the Editorial Team has been having since JASC’s inception around what we mean by 'transformative'.
Oliver Koenig +7 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Auslegung: a Journal of Philosophy, 1979 Many contemporary philosophers advocate the thesis that knowing implies knowing that one knows (KK thesis). In particular,, this thesis is explicitly argued for by Risto Hilpinen. In this essay, I shall (1) briefly spell out the gist of the KK thesis as presented by Hilpinen, (2) review two intuitive responses to the KK thesis made by David Rynin, and ...
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source