Results 111 to 120 of about 2,678,948 (305)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Open Rivers, 2015 We asked a diverse group of river people to respond to the prompt “How did you come to know the Mississippi River? What does it mean, to you, to know the Mississippi River?” We present below a few of the responses, in no particular order.
Sharon Day, Bernard Williams, Christopher Morris, Conevery Bolton Valencius, Craig Colten
doaj +1 more source
Embodied ways of knowing. [PDF]
, 2004 In this article I present an argument for `embodied ways of knowing' as an alternative epistemological strategy, drawing on feminist research and embodied experience.
Barbour, Karen
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Thought Experiments and Novels
Studia Humana, 2019 Novels and thought experiments can be pathways to different kinds of knowledge. We may, however, be hard pressed to say exactly what can be learned from novels but not from thought experiments.
Milligan Tony
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
What our Rylean Ancestors Knew:\ud More on Knowing How and Knowing That [PDF]
, 2003 In their recent article "Knowing How,�1 Jason Stanley and\ud Timothy Williamson deny that there is a fundamental\ud distinction between knowing-how and knowing-that,\ud claiming instead that knowledge-how is rather a form of\ud knowledge-that.
Shieber, Joseph
core