Results 91 to 100 of about 1,037,693 (300)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Bureaucratic culture, empowering leadership, affective commitment, and knowledge sharing behavior in Indonesian government public services

Cogent Business & Management, 2019
This paper aims to clarify the relationship among bureaucratic culture, empowering leadership, knowledge sharing behavior and affective commitment in the Indonesian public sector organizations.
Hendryadi, Suratna, Suryani, B. Purwanto
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Dynamic Evolution of Knowledge Sharing Behavior among Enterprises in the Cluster Innovation Network Based on Evolutionary Game Theory

Sustainability, 2019
Knowledge sharing behavior based on the cluster innovation network has become the primary measure for enterprises to realize sustainable innovation. In order to promote the proactive knowledge sharing behavior among enterprises in the long term, the ...
Xiaodan Kong, Qi Xu, T. Zhu
semanticscholar   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Explore Knowledge-Sharing Strategy and Evolutionary Mechanism for Integrated Project Team Based on Evolutionary Game Model

Advances in Civil Engineering, 2019
Integrated Project Delivery (IPD) has become increasingly popular in the architecture, engineering, and construction industries. However, the current practice status by the construction industry fails to deliver the desired results. In that backdrop, how
Yanchao Du, Hengyu Zhou, Yongbo Yuan, Xiaoxue Liu   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Determinants of Preschool Teachers' Knowledge-Sharing Behavior from a Thinking Style Perspective. [PDF]

Behav Sci (Basel), 2023
Cheng L, Wu D, Cao J.
europepmc   +1 more source

Knowledge sharing among medical teachers: the interplay between personality and the theory of planned behavior

BMC Medical Education
Introduction Knowledge sharing is critical to the quality of medical education and healthcare services. However, medical teachers encounter multiple barriers, such as content dispersion and a lack of shared knowledge management. Using structural equation
Hatam Faraji Dehsorkhi, Ali Asghar Hayat
doaj   +1 more source