Results 91 to 100 of about 1,325,679 (296)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Jurnal Ilmiah Bisnis dan Ekonomi AsiaThe purpose of this study was to explore the extent to which the influence of knowledge sharing behavior on innovative work behavior and employee job satisfaction with motivational language as a moderating variable.
Mai Yuliza +2 more
doaj +1 more source
Why are technological spillovers spatially bounded ? A market orientated approach. [PDF]
According to empirical evidence, technological spillovers are spatially bounded. This is one of the main reasons why firms are induced to locate in close prox-imity despite tough competition. This paper is an attempt to endogenize such spillovers.
Baranes, E., Tropeano, J.-P.
core
Why Would Anyone Like To Share His Knowledge? [PDF]
, 2001 Why do workers within organizations, or organizations in a network share information and knowledge? This question reverses the logic in some of the knowledge management literature, which addresses impediments and problems in information and knowledge ...
Homburg, V.M.F. (Vincent) +1 more
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
BMC Medical EducationIntroduction Knowledge sharing is critical to the quality of medical education and healthcare services. However, medical teachers encounter multiple barriers, such as content dispersion and a lack of shared knowledge management. Using structural equation
Hatam Faraji Dehsorkhi, Ali Asghar Hayat
doaj +1 more source
Advances in Civil Engineering, 2019 Integrated Project Delivery (IPD) has become increasingly popular in the architecture, engineering, and construction industries. However, the current practice status by the construction industry fails to deliver the desired results. In that backdrop, how
Yanchao Du +3 more
doaj +1 more source
Asian Journal of Technology Management, 2019 . Telkom CorpU has expert who have been recognized as employees with particular skill and experience. But based on data, some expert feel knowledge sharing is not already become culture among them. Indeed, knowledge sharing is a vital part from knowledge
Rezka Andria Tirana +1 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source