Results 91 to 100 of about 21,998,049 (389)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Knowledge embedded [PDF]

open access: yes, 2019
How should we account for the contextual variability of knowledge claims? Many philosophers favour an invariantist account on which such contextual variability is due entirely to pragmatic factors, leaving no interesting context-sensitivity in the ...
Kindermann, Dirk
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

An integration of competing accounts on children’s number line estimation

open access: yesFrontiers in Psychology, 2015
Children’s estimation patterns in bounded number line estimation reveal marked developmental changes. Three different theoretical accounts were proposed to explain these changes: a log-to-linear shift account, a proportion-judgment account and a two ...
Tanja eDackermann   +6 more
doaj   +1 more source

Discussion paper: Disability and poverty reduction strategies: How to ensure that access of persons with disabilities to decent and productive work is part of the PRSP process [PDF]

open access: yes, 2002
[Excerpt] In 1999, the IMF and the World Bank launched the Poverty Reduction Strategy Paper (PRSP) approach to poverty reduction in low-income countries in order to ensure that concessional funding through the IMF’s Poverty Reduction and Growth ...
InFocus Programme on Skills, Knowledge and Employability   +1 more
core   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Frictionless Data: Making Research Data Quality Visible

open access: yesInternational Journal of Digital Curation, 2018
There is significant friction in the acquisition, sharing, and reuse of research data. It is estimated that eighty percent of data analysis is invested in the cleaning and mapping of data (Dasu and Johnson,2003).
Dan Fowler, Jo Barratt, Paul Walsh
doaj   +1 more source

Sri Lanka Country Profile [PDF]

open access: yes, 2003
[From Introduction] This country study for Sri Lanka is part of the ILO project \u27Employment of People with Disabilities – the Impact of Legislation\u27 which aims to enhance the capacity of national governments in selected countries of Asia and East ...
InFocus Programme on Skills, Knowledge and Employability   +1 more
core   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

On the interrelation of multiplication and division in secondary school children

open access: yesFrontiers in Psychology, 2013
Multiplication and division are conceptually inversely related: Each division problem can be transformed into as a multiplication problem and vice versa.
Stefan eHuber   +4 more
doaj   +1 more source

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