Results 51 to 60 of about 14,157,059 (194)

Do B-1 cells play a role in response to Mycobacterium tuberculosis Beijing lineages?

Virulence, 2022
We highlight the need to include an analysis of the B-1 B cell subset to complement the characterization of the cell-mediated immune response to the Mycobacterium tuberculosis Beijing lineage.
Fermín Acosta, Patricia L. Fernández, Amador Goodridge   +2 more
doaj   +1 more source

OAK: Ontology-Based Knowledge Map Model for Digital Agriculture [PDF]

, 2020
Nowadays, a huge amount of knowledge has been amassed in digital agriculture. This knowledge and know-how information are collected from various sources, hence the question is how to organise this knowledge so that it can be efficiently exploited. Although this knowledge about agriculture practices can be represented using ontology, rule-based expert ...
arxiv   +1 more source

False certainty in the acquisition of anatomical and physiotherapeutic knowledge

BMC Medical Education, 2022
Background Efficient metacognitive monitoring, that is the monitoring of one’s own thought processes and specifically one’s state of knowledge, is essential for effective clinical reasoning.
Johannes von Hoyer, Martina Bientzle, Ulrike Cress, Johannes Grosser, Joachim Kimmerle, Peter Holtz   +5 more
doaj   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Budgeting of non-commercial clinical trials: development of a budget tool by a public funding agency

Trials, 2019
Background Investigator-led multicentre randomised trials are essential to generate evidence on the optimal use of medical interventions. These non-commercial trials are often hampered by underfunding, which may lead to difficulties in gathering a team ...
Hilde Nevens, Jillian Harrison, France Vrijens, Leen Verleye, Nelle Stocquart, Elisabeth Marynen, Frank Hulstaert   +6 more
doaj   +1 more source

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Towards a Universal Continuous Knowledge Base [PDF]

arXiv, 2020
In artificial intelligence (AI), knowledge is the information required by an intelligent system to accomplish tasks. While traditional knowledge bases use discrete, symbolic representations, detecting knowledge encoded in the continuous representations learned from data has received increasing attention recently.
arxiv  

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Open Knowledge Maps: Visuelle Literatursuche basierend auf den Prinzipien von Open Science

Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2019
Die Wissenschaft befindet sich in einer Auffindbarkeitskrise. Obwohl durch die Open Access-Bewegung Forschungsergebnisse besser zugänglich geworden sind, wird ein signifikanter Teil der Outputs nicht nachgenutzt.
Peter Kraker, Maxi Schramm, Christopher Kittel   +2 more
doaj   +1 more source