Results 81 to 90 of about 21,842,130 (342)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2019 How should we account for the contextual variability of knowledge claims? Many philosophers favour an invariantist account on which such contextual variability is due entirely to pragmatic factors, leaving no interesting context-sensitivity in the ...
Kindermann, Dirk
core +1 more source
Knowledge Crash and Knowledge Management [PDF]
International Journal of Knowledge and Systems Science, 2010 Population ageing is a phenomenon that is quite new and irreversible in the history of mankind. Every country and every organisation is concerned while it is not certain that all the risks and challenges have been clearly identified. Clearly, there is a risk of massive knowledge loss, i.e., “Knowledge Crash”, due to massive retirements, but not ...
openaire +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Exploring the Meaning of Fatherhood in Guguletu [PDF]
, 2013 This was a study conducted by a Gender Studies Honours student who collaborated with the NGO Ikamva Labantu in Guguletu. The NGO was interested in understanding men's involvement as fathers and what support they needed for this role. The aim of the study
UCT Knowledge Co-op
core
BMC Health Services ResearchBackground Long-term care and retirement homes (LTCH/RH) faced systemic challenges that were exacerbated by the COVID-19 pandemic. Homes faced three major challenges over the course of the pandemic: implementing infection prevention and control (IPAC ...
Christine Fahim +15 more
doaj +1 more source
Accessible Knowledge—Knowledge on Accessibility [PDF]
Journal of Civil Engineering and Architecture, 2015 Although serious efforts are made internationally and nationally, it is a slow process to make our physical environment accessible. In the actual design process, architects play a major role. But what kinds of knowledge– including research-based knowledge – do practicing architects make use of when designing accessible environments?
openaire +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
, 2003 [From Introduction] This country study for India is part of the ILO project \u27Employment of People with Disabilities – the Impact of Legislation\u27 which aims to enhance the capacity of national governments in selected countries of Asia and East ...
InFocus Programme on Skills, Knowledge and Employability +1 more
core +1 more source
Open Knowledge Maps: Visuelle Literatursuche basierend auf den Prinzipien von Open Science
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2019 Die Wissenschaft befindet sich in einer Auffindbarkeitskrise. Obwohl durch die Open Access-Bewegung Forschungsergebnisse besser zugänglich geworden sind, wird ein signifikanter Teil der Outputs nicht nachgenutzt.
Peter Kraker +2 more
doaj +1 more source