Results 81 to 90 of about 5,080,203 (297)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Accessible Knowledge—Knowledge on Accessibility [PDF]
Journal of Civil Engineering and Architecture, 2015 Although serious efforts are made internationally and nationally, it is a slow process to make our physical environment accessible. In the actual design process, architects play a major role. But what kinds of knowledge– including research-based knowledge – do practicing architects make use of when designing accessible environments?
openaire +1 more source
The effects of home and school on children’s happiness: a structural equation model
International Journal of Child Care and Education Policy, 2018 This study analyzed the structural relationships between the important constructs of school, home and family, and the happiness of Abu Dhabi school children. Survey data were collected from students in schools in the three regions of Abu Dhabi. The final
Masood Badri +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
An integration of competing accounts on children’s number line estimation
Frontiers in Psychology, 2015 Children’s estimation patterns in bounded number line estimation reveal marked developmental changes. Three different theoretical accounts were proposed to explain these changes: a log-to-linear shift account, a proportion-judgment account and a two ...
Tanja eDackermann +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Frictionless Data: Making Research Data Quality Visible
International Journal of Digital Curation, 2018 There is significant friction in the acquisition, sharing, and reuse of research data. It is estimated that eighty percent of data analysis is invested in the cleaning and mapping of data (Dasu and Johnson,2003).
Dan Fowler, Jo Barratt, Paul Walsh
doaj +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Engaging online students by activating ecological knowledge [PDF]
, 2020 Stacy L. Hines +6 more
openalex +1 more source