Results 81 to 90 of about 20,717,061 (414)
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Budgeting of non-commercial clinical trials: development of a budget tool by a public funding agency
Trials, 2019 Background Investigator-led multicentre randomised trials are essential to generate evidence on the optimal use of medical interventions. These non-commercial trials are often hampered by underfunding, which may lead to difficulties in gathering a team ...
Hilde Nevens +6 more
doaj +1 more source
BMC Medicine, 2023 Background Chronic disease management (CDM) through sustained knowledge translation (KT) interventions ensures long-term, high-quality care. We assessed implementation of KT interventions for supporting CDM and their efficacy when sustained in older ...
Areti Angeliki Veroniki +27 more
doaj +1 more source
Towards a Universal Continuous Knowledge Base [PDF]
arXiv, 2020 In artificial intelligence (AI), knowledge is the information required by an intelligent system to accomplish tasks. While traditional knowledge bases use discrete, symbolic representations, detecting knowledge encoded in the continuous representations learned from data has received increasing attention recently.
arxiv
Learning Entity and Relation Embeddings for Knowledge Graph Completion
AAAI Conference on Artificial Intelligence, 2015 Knowledge graph completion aims to perform link prediction between entities. In this paper, we consider the approach of knowledge graph embeddings.
Yankai Lin +4 more
semanticscholar +1 more source
, 2017 This chapter provides an introduction to and overview of the knowledge commons research framework. Knowledge commons refers to an institutional approach (commons) to governing the production, use, management, and/or preservation of a particular type of resource (knowledge).
Madison, Michael J +2 more
openaire +6 more sources
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Do B-1 cells play a role in response to Mycobacterium tuberculosis Beijing lineages?
Virulence, 2022 We highlight the need to include an analysis of the B-1 B cell subset to complement the characterization of the cell-mediated immune response to the Mycobacterium tuberculosis Beijing lineage.
Fermín Acosta +2 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
An Integrated Model for User Innovation Knowledge Based on Super-network [PDF]
arXiv, 2019 Online user innovation communities are becoming a promising source of user innovation knowledge and creative users. With the purpose of identifying valuable innovation knowledge and users, this study constructs an integrated super-network model, i.e., User Innovation Knowledge Super-Network (UIKSN), to integrate fragmented knowledge, knowledge fields ...
arxiv