Results 71 to 80 of about 7,833,055 (290)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
MathematicsEvent argument extraction is a crucial subtask of event extraction, which aims at extracting arguments that correspond to argument roles when given event types.
Lijun Tan +3 more
doaj +1 more source
Defining a Relation between Phenomenal Knowledge and Physical Knowledge [PDF]
حکمت و فلسفهWhat is the relation between phenomenal concepts and physical concepts? In this paper, I try to propose an answer to this question with regard to the Knowledge Argument and Mary Thought Experiment.
Masoud Ghafari
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hume’s “Of scepticism with regard to reason” and the Degeneration of Knowledge in Practice
Journal of Modern PhilosophyHume’s “Of scepticism with regard to reason” opens with an argument that is supposed to show how “all knowledge degenerates into probability” (T 1.4.1.1; SBN 180).
Benjamin Nelson
doaj +2 more sources
How the researcher’s experience of visual images can contribute to qualitative research
Akademisk Kvarter, 2014 This article presents a theoretical argument exploring how visual images appeal to sensory knowledge, and how sensory knowledge can contribute to qualitative research where visual images are included as part of the method.
Anne Maj Nielsen
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Conhecimento, Verdade e Significado
DoisPontos, 2009 This paper’s goal is to present a Wittgenstein’s argument against philosophical realism, the strong realism with respect to truth. Wittgenstein’s argument has the general form of a modus tollens whose conditional premise states that strong realism ...
Alexandre N. Machado
doaj
Clive’a S. Lewisa argument z pragnień przeciwko naturalizmowi
Studia Philosophiae Christianae, 2020 This article outlines a number of formulations of C.S. Lewis’s anti-naturalistic argument from desire. We tackle the problem of the logical validity of this argument and its weak points as characterized in the relevant literature, including objections ...
Piotr Bylica
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