Results 81 to 90 of about 7,833,055 (290)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

DESCARTES VE ÖZNE OLARAK BENLİK

open access: yesFelsefe Dünyası, 2003
In this paper, Descartes' theory of self and self-knowledge is being examined. Descartes claims that self-knowledge has a special status, and is more certain that sensory knowledge, because while it is acquired directly through an intellectual ...
Sahabettin Yalçın
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Phenomenal knowledge why: the explanatory knowledge argument against physicalism [PDF]

open access: yes, 2019
Phenomenal knowledge is knowledge of what it is like to be in conscious states, such as seeing red or being in pain. According to the knowledge argument (Jackson 1982, 1986), phenomenal knowledge is knowledge that, i.e., knowledge of phenomenal facts ...
Mørch, Hedda Hassel
core   +2 more sources

Story Similarity in Arguments from Analogy

open access: yesInformal Logic, 2012
In this paper a hybrid model of argument from analogy is presented that combines argumentation schemes and story schemes. One premise of the argumentation scheme for argument from analogy in the model claims that one case is similar to another.
Douglas Walton
doaj   +3 more sources

Averroesian Religious Common Sense Natural Theology as Reflective Knowledge in the Form of Teleological Argument

open access: yesReligions
In his Middle Commentary on Posterior Analytics, the great Aristotelian Commentator Ibn Rushd defines “knowledge” (scientific knowledge, epistemē, ‘ilm) as one of Aristotle’s five intellectual virtues and the faculty of reason, akin to the other virtues,
Kemal Batak
doaj   +1 more source

A Framework for Content Area Writing: Mediators and Moderators [PDF]

open access: yesJournal of Writing Research, 2010
Writing can be a tool for communicating and learning in content area subjects. This pretest-posttest quasi-experiment examined the effects of instruction in a content area writing framework on students’ text quality and ability to use writing to learn ...
Perry D. Klein, Lori C. Kirkpatrick
doaj  

Necessary truths, evidence, and knowledge

open access: yesFilosofia Unisinos, 2016
According to the knowledge view of evidence notoriously defended by Timothy Williamson (2000), for any subject, her evidence consists of all and only her propositional knowledge (E=K). Many have found (E=K) implausible.
Art?rs Logins
doaj   +1 more source

Knowledge and Argument

open access: yesNoûs
ABSTRACT I argue that knowledge plays a distinctive role in psychological explanation that weaker epistemic states cannot because it is robust in the face of counterevidence in a way that they are not. Being robust in the face of counterevidence makes your belief robust in the face of counterargument.
openaire   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

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