Results 81 to 90 of about 9,383,085 (340)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Hypersensing Creative Acts. The Role of Design in Transmitting Intangible Cultural Heritage through Digital Tools [PDF]
Pad, 2022 Craft objects represent material culture, artisans’ heterogeneous know-how shaped into tangible artefacts as results of creative acts, evidence of an “intimate connection between hand and head”.
Daria Casciani, Angelica Vandi
doaj
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Knowledge Creation as a Square Dance on the Hilbert Cube [PDF]
This paper presents a micro-model of knowledge creation and transfer in a small group of people. Our model incorporates two key aspects of the cooperative process of knowledge creation: (i) heterogeneity of people in their state of knowledge is essential
Marcus Berliant, Masahisa Fujita
core
A survey of epistemology and its implications on an organisational information and knowledge management model [PDF]
, 2008 This is a theoretical paper which aims to integrate various epistemologies from the philosophical, knowledge management, cognitive science, and educational perspectives.
Kor, AL, Orange, G
core
Post-Project Market Review as a tool for stimulating commercialisation of knowledge creation projects [PDF]
, 2006 This paper handles about the introduction of a post-project market review, which is based on the concept of post-project reviews to stimulate commercialisation. It will start with a brief description of the case-company.
Bout, Liesbeth Y. +3 more
core +4 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Evolving Scholar, 2022 This paper seeks to identify how users and architects through collaborations are generating knowledge on Universal Design (UD). Besides the need for architects to build a solid foundation of architectural knowledge, insight in users’ life practices is essential in UD knowledge creation.
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source