Results 71 to 80 of about 8,364,979 (244)

More Stable Ties or Better Structure? An Examination of the Impact of Co-author Network on Team Knowledge Creation

open access: yesFrontiers in Psychology, 2017
This study aims to explore the influence of co-author network on team knowledge creation. Integrating the two traditional perspectives of network relationship and network structure, we examine the direct and interactive effects of tie stability and ...
Mingze Li   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Organizational knowledge creation [PDF]

open access: yes
The purpose of this paper is to present an overview of the state-ofthe- art in organizational knowledge creation, a field of research that is expanding almost exponentially.
Constantin BRATIANU, Ivona ORZEA
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

VirtualModeling Laboratories for Knowledge Integration and Creation [PDF]

open access: yes, 2005
This paper deals with one of the key issues of modeling work: how model-based complex problem solving can efficiently exploit huge amounts of knowledge available on a countless number of interconnected computers.
Marek, Makowski
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Trialogical Design Principles as Inspiration for Designing Knowledge Practices for Medical Simulation Training

open access: yes, 2012
This chapter discusses introduction of the trialogical approach to simulation training courses for medical teams involved in neonatal resuscitation. We analysed and developed knowledge practices in a tradition-laden educational context, which has not ...
Klas Karlgren, Karlgren, K,
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Mediating Role of Organizational Creativity between Employees’ Intention in Knowledge Management Process and Organizational Performance: Empirical Study on Pharmaceutical Employees [PDF]

open access: yesPakistan Journal of Commerce and Social Sciences, 2019
Companies try to put efforts in upgrading the intellectual capital and leveraging them to develop and sustain competitive advantage in the business. Considering this view, the study unpacks the relation between knowledge management process (KMP) and ...
Hira Riaz , Atif Hassan
doaj  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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