Results 101 to 110 of about 1,934,537 (295)

Integrating musicological knowledge into a probabilistic framework for chord and key extraction [PDF]

open access: yes, 2010
In this contribution a formerly developed probabilistic framework for the simultaneous detection of chords and keys in polyphonic audio is further extended and validated.
Martens, Jean-Pierre, Pauwels, Johan
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Unsupervised improvement of named entity extraction in short informal context using disambiguation clues [PDF]

open access: yes, 2012
Short context messages (like tweets and SMS’s) are a potentially rich source of continuously and instantly updated information. Shortness and informality of such messages are challenges for Natural Language Processing tasks.
Habib, Mena B., Keulen, Maurice van
core   +2 more sources

Gaining Insight by Structural Knowledge Extraction

open access: yes, 2016
The availability of increasingly larger and more complex datasets has boosted the demand for systems able to analyze them automatically. The design and implementation of effective systems requires coding knowledge about the application domain inside the system itself; however, the designer is expected to intuitively grasp the most relevant features of ...
Pietro Cottone   +3 more
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Long-tail Relation Extraction via Knowledge Graph Embeddings and Graph Convolution Networks

open access: yes, 2019
We propose a distance supervised relation extraction approach for long-tailed, imbalanced data which is prevalent in real-world settings. Here, the challenge is to learn accurate "few-shot" models for classes existing at the tail of the class ...
Chen, Huajun   +6 more
core  

Knowledge Extraction and Knowledge Integration governed by Łukasiewicz Logics

open access: yesCoRR, 2016
The development of machine learning in particular and artificial intelligent in general has been strongly conditioned by the lack of an appropriate interface layer between deduction, abduction and induction. In this work we extend traditional algebraic specification methods in this direction.
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

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