Results 131 to 140 of about 321,049 (289)

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

open access: yesAdvanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin   +7 more
wiley   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

open access: yesAdvanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen   +31 more
wiley   +1 more source

Reliable AI Platform for Monitoring BCI Caused Brain Injury and Providing Real‐Time Protection

open access: yesAdvanced Science, EarlyView.
BrainGuard enables real‐time and interpretable assessment of brain injury caused by brain computer interface (BCI). Using feature‐based Gaussian process (GP) emulators trained on limited biomechanical data, it efficiently predicts full‐field strain and constructs patient‐specific digital brain twins to support clinical diagnosis and long‐term BCI ...
Chufan He   +3 more
wiley   +1 more source

Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes

open access: yesAdvanced Science, EarlyView.
Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji   +12 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

open access: yesAdvanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong   +6 more
wiley   +1 more source

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