Results 51 to 60 of about 1,444,306 (236)

Risk terrain modeling for monitoring illicit drugs markets across Bogota, Colombia

Crime Science, 2018
Colombia has gone from being a producer and exporter of illicit drugs to becoming a country where consumption also plays an important role. In Bogota, as result of specific policies adopted by the authorities that hit illicit drugs hot spots, the sale ...
José A. Escudero, Boris Ramírez
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Krishikosh: A digital repository to disseminate agricultural knowledge

The Indian Journal of Agricultural Sciences, 2018
Krishikosh is a versatile open access digital repository catering to the needs of Indian National Agricultural Research and Education System (NARES) and has architecture of centralized hosting of content but decentralized management.
RAKHEE SHARMA, AMRENDER KUMAR, P S PANDEY, HIMANSHU HIMANSHU, MANSI GUPTA, SANJIV KAPUR, ASHISH SHARMA, A K JAIN   +7 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Resilience in the Vaccine Supply Chain: Learning from the COVID-19 Pandemic

Vaccines
Background: The COVID-19 pandemic revealed vaccine supply chain (VSC) weaknesses and enabled post-pandemic analysis highlighting the growing importance of supply chain resilience.
Megan Hay, Anika Teichert, Sarah Kilz, Agnes Vosen   +3 more
doaj   +1 more source

Knowledge Dissemination based on Social Networks: A Systematic Review [PDF]

کتابداری و اطلاع‌رسانی
Objective: Knowledge is an asset that increases when others share it, and its sharing and dissemination leads to synergy and growth of individual and collective knowledge.
Leila Jabbari, Mohammad Hasanzadeh, Fatemeh Zandian, Atefeh Sharif   +3 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Effect of Book Therapy on Mental Health of Prisoners (Case Study: Defamation of Women in Shahr-e-Rey, Iran)

مدیریت اطلاعات سلامت, 2019
Introduction: Book therapy is an effective and practical process that can prevent or reduce a range of mental health problems. Prisoners are among the most in need of attention in terms of mental health.
Fatemeh Zandian, Fatemeh Valipour, Mohamad Hasanzadeh   +2 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source