Results 61 to 70 of about 9,418,995 (309)

Knowledge maps: An essential technique for conceptualisation [PDF]

Data & Knowledge Engineering, 2000
The process of conceptualisation is a fundamental problem-solving activity and, hence, is an essential activity for solving the problem of software systems construction. This paper first analyses the process of conceptualisation generally, that is, not as applied specifically to software systems, and establishes a general-purpose conceptualisation ...
Gómez-Pérez, A., Moreno Sánchez-Capuchino, Ana María, Pazos Sierra, Juan, Sierra Alonso, Almudena   +3 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Social, Clinical, and Behavioral Determinants of HIV Infection and HIV Testing among Black Men in Toronto, Ontario: A Classification and Regression Tree Analysis

Journal of the International Association of Providers of AIDS Care, 2020
Black men bear a disproportionate burden of HIV infection. These HIV inequities are influenced by intersecting social, clinical, and behavioral factors.
Pascal Djiadeu MSc, PhD, Martez D. R. Smith LMSW, Sameer Kushwaha MD, Apondi J. Odhiambo MPH, David Absalom MPH, Winston Husbands PhD, Wangari Tharao MEd, Rotrease Regan PhD, RN, MPH, Ting Sa MS, Nanhua Zhang PhD, Rupert Kaul MD, PhD, LaRon E. Nelson PhD, RN, FNP, FNAP, FAAN   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Developing a Research Agenda for HiAP Implementation: A Response to the Recent Commentaries [PDF]

International Journal of Health Policy and Management, 2023
Maria Guglielmin, Ketan Shankardass, Patricia O'Campo, Ahmed M. Bayoumi, Lauri Kokkinen, Carles Muntaner   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Validation of a standardised approach to collect sociodemographic and social needs data in Canadian primary care: cross-sectional study of the SPARK tool

BMJ Open
Objective This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources (‘SPARK Tool’) against comparison questions from well-established national surveys (Post Survey ...
Kris Aubrey-Bassler, Alan Katz, Emily Gard Marshall, Itunuoluwa Adekoya, Nazeem Muhajarine, Andrew David Pinto, Alannah Delahunty-Pike, Dana Howse, Leanne Kosowan, Abigail Zita Seshie, Eunice Abaga, Jane Cooney, Marjeiry Robinson, Dorothy Senior, Alexander Zsager, Joseph J O’Rourke, Cory Neudorf, Mandi Irwin   +17 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Understanding the role and organization of health workers delivering non-communicable disease management in primary care in low- and middle-income countries: a scoping review

BMC Primary Care
Background Non-communicable diseases are responsible for three-fourths of annual deaths worldwide and disproportionately affect individuals living in low- and middle-income countries.
Archna Gupta, Oluwasegun J. Ogundele, Roxana Rabet, Iryna Artyukh, Thiago Trindade, Doret Cheng, Daniel Osafo Darko, Mai Eltigany, Alarcos Cieza, Becky Skidmore, Katherine D. Rouleau   +10 more
doaj   +1 more source