Results 71 to 80 of about 9,418,995 (309)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Southeast Asia 1:250,000 [cartographic material] /

, 1954
Various eds. "Constructed and molded in ... from ... 1:250,000, Series 1501 ..."; Also shows aeronautical information.; Includes index to adjoining sheets and glossary.; Raised relief model map series of Southeast Asia (Thailand and Indochina) showing ...
United States. Army Map Service.
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Natural hazards map of the Circum-Pacific Region [cartographic material] : Pacific Basin sheet /

, 1992
Map modified 1992.; Depths shown by isolines.; "This map is a contribution to the International Decade for Natural Disaster Reduction (IDNDR)."; Accompanied by: Explanatory notes for the Natural hazards map of the Circum-Pacific region Pacific Basin ...
Circum-Pacific Map Project.
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospect Green Map: a community map of environmental, historical, cultural, civic, and recreational sites

A map detailing the sites of interest and importance in the Prospect, NC, and the Robeson County area of North Carolina.
Robeson County Green Map Project
core   +1 more source

Primary care provider and clinic staff perspectives on the collection of demographic and social needs data in primary care clinics across five Canadian provinces

Family Medicine and Community Health
Objective This study reports on the barriers and facilitators experienced by primary care providers, clinic staff and clinic leadership when implementing the SPARK Tool to collect demographic and social needs data in primary care clinics across Canada ...
Kris Aubrey-Bassler, Emily Gard Marshall, Itunuoluwa Adekoya, Nazeem Muhajarine, Archna Gupta, Mélanie Ann Smithman, Alannah Delahunty-Pike, Dana Howse, Leanne Kosowan, Abigail Zita Seshie, Eunice Abaga, Marjeiry Robinson, Alexander Zsager, Cory Neudorf, Joseph J. O’Rourke, Lane Williams, Isabelle Fortuna, Andrew D. Pinto   +17 more
doaj   +1 more source