Results 91 to 100 of about 633,162 (316)

Specific Type of Knowledge Map: Mathematical Model [PDF]

, 2005
The article deals with relationships between mathematical models and knowledge maps. The goal of the article is to suggest how to use the mathematical model as a knowledge map and/or as a part (esp. the inference mechanism) of the knowledge system.
Milan, Houška, Martina, Beránková
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Japan essential medicine list and medicine supply issues: a cross-sectional study

Journal of Pharmaceutical Policy and Practice
Background Essential medicines lists aim to improve access, affordability, and quality of medicines, though their impact on pricing and supply varies. Japan’s universal coverage addresses key EML policy areas but faces drug shortages linked to generic ...
Camila Heredia, Hayase Hakariya, Akihiko Ozaki, Navindra Persaud   +3 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Diocese of Adelaide [cartographic material]

Map showing the Diocese of Adelaide, particularly locations of churches and towns.; Prime meridian: Greenwich.; Plate [25] from: The Colonial Church Atlas, Third edition, London: Society for Promoting Christian Knowledge, [1850]; Also available online ...
Society for Promoting Christian Knowledge (Great Britain)
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Interprofessional teams and capacity in collaborative primary care: a rapid scoping review

Systematic Reviews
Purpose Interprofessional team-based primary care models are pursued often as a means to improve access to primary care services and increase capacity within the health system for more patients to be served.
Hina Ansari, Dipika Neupane, Noah Ivers, Tara Kiran, Sai Surabi Thirugnanasampanthar, Jasmeen Dourka, Lyn M. Sibley, Paul A. Khan, Vera Nincic, Rachel Thelen, Sydney Pearce, Kanya Rajendra, Cris Carter, Danielle Martin, Jane Zhao, Marianna Kong, Andrea C. Tricco   +16 more
doaj   +1 more source

Coast of Labrador [cartographic material] /

Map of the coast of Labrador, Canada, showing coastal towns and geographical features.; Prime meridian: Greenwich.; Plate [3] from: The Colonial Church Atlas, Third edition, London: Society for Promoting Christian Knowledge, [1850]; Also available online
Society for Promoting Christian Knowledge (Great Britain)
core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source