Results 101 to 110 of about 5,403,631 (298)
Development of a measure of knowledge use by stakeholders in rehabilitation technology
SAGE Open Medicine, 2014 Objectives: Uptake of new knowledge by diverse and diffuse stakeholders of health-care technology innovations has been a persistent challenge, as has been measurement of this uptake.
Vathsala I Stone +5 more
doaj +1 more source
An Innovation Index Based on Knowledge Capital Investment: Definition and Results for the UK Market Sector [PDF]
We (a) propose an implementable innovation index, (b) relate it to existing innovation definitions and (c) show whole-economy and industry-specific results for the UK market sector, 2000-2005.
Clayton, Tony +2 more
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Choosing Attribute Weights for Item Dissimilarity using Clikstream Data with an Application to a Product Catalog Map [PDF]
In content- and knowledge-based recommender systems often a measure of (dis)similarity between items is used. Frequently, this measure is based on the attributes of the items. However, which attributes are important for the users of the system remains an
Groenen, P.J.F. +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Franklin OpenThe role of Interval-valued Neutrosophic Knowledge measures and Entropy measures is crucial. The main objective of this manuscript is to study the knowledge measures that apply to decision-making problems for interval-valued neutrosophic sets.
Amandeep Singh, Satish Kumar
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
The Indonesian Journal of Public HealthIntroduction: In mid-2022, a Central Statistics Agency (BPS) survey reported that Indonesian people's compliance with COVID-19 prevention measures ranged between 70-84%.
Sulistyawati Sulistyawati +2 more
doaj +1 more source