Results 101 to 110 of about 2,423,181 (299)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Semantic Integration of Heterogeneous Data Sources Using Ontology-Based Domain Knowledge Modeling for Early Detection of COVID-19. [PDF]
SN Comput Sci, 2022 Thirumahal R +2 more
europepmc +1 more source
, 2015 Top-performing machine learning systems, such as deep neural networks, large ensembles and complex probabilistic graphical models, can be expensive to store, slow to evaluate and hard to integrate into larger systems. Ideally, we would like to replace such cumbersome models with simpler models that perform equally well.
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Pattern of Substance Use and Related Factors in Male Prisoners [PDF]
Addiction and Health, 2016 Background: Prisoner’s addiction is one of the major problems in many countries which imposes very high medical costs and social harm to communities. This study investigated the pattern of substance use and related factors in male prisoners in one of the
Ali Khalooei +3 more
doaj
Probabilistic domain-knowledge modeling of disorder pathogenesis for dynamics forecasting of acute onset. [PDF]
Artif Intell Med, 2021 Huynh PK, Setty A, Phan H, Le TQ.
europepmc +1 more source
Impact of climate induced glacial melting on coastal marine systems in the Western Antarctic Peninsula region [PDF]
, 2012 IMCOAST is an international research program that features a multidisciplinary approach involving geo and biological sciences, field investigations, remote sensing and modeling and knowledge into the hydrographical and biological history of the marine ...
Abele, Doris +3 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Clinical Decision Support System Based on Hybrid Knowledge Modeling: A Case Study of Chronic Kidney Disease-Mineral and Bone Disorder Treatment. [PDF]
Int J Environ Res Public Health, 2021 Ali SI +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source