Results 111 to 120 of about 2,443,581 (299)

A template-based knowledge reuse method for generating multitype 3D railway scenes

open access: yesInternational Journal of Digital Earth, 2018
Constructing 3D railway scenes helps improve the railway information construction ability and the comprehensive railway management level. However, the existing modeling methods have disadvantages such as low flexibility in scene configuration, weak ...
Heng Zhang   +7 more
doaj   +1 more source

Whole patient knowledge modeling of COVID-19 symptomatology reveals common molecular mechanisms. [PDF]

open access: yesFront Mol Med, 2022
Brock S   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Engineering technology for networks [PDF]

open access: yes
Space Network (SN) modeling and evaluation are presented. The following tasks are included: Network Modeling (developing measures and metrics for SN, modeling of the Network Control Center (NCC), using knowledge acquired from the NCC to model the SNC ...
Benjamin, Norman, Paul, Arthur S.
core   +1 more source

Knowledge management initiatives, innovation and GLC performance [PDF]

open access: yes, 2009
A model of knowledge management initiatives, innovation and performance evaluation was developed and tested on listed Malaysian Government-Linked companies (GLC).
A. Rahman, Badruddin   +1 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Pattern of Substance Use and Related Factors in Male Prisoners [PDF]

open access: yesAddiction and Health, 2016
Background: Prisoner’s addiction is one of the major problems in many countries which imposes very high medical costs and social harm to communities. This study investigated the pattern of substance use and related factors in male prisoners in one of the
Ali Khalooei   +3 more
doaj  

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