Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Legal linguistic templates and the tension between legal knowledge representation and reasoning. [PDF]
Front Artif Intell, 2023 Libal T.
europepmc +1 more source
The Knowledge Representation and Semantic Reasoning Realization of Productivity Grade Based on Ontology and SWRL [PDF]
, 2012 Li Ma, Helong Yu, Yue Wang, Guifen Chen
openalex +1 more source
A Test of Learning Progress Models Using an AI-Enabled Knowledge Representation System [PDF]
, 2023 Min Kyu Kim +3 more
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Knowledge Representation and Management: Notable Contributions in 2021. [PDF]
Yearb Med Inform, 2022 Cui L, Dhombres F, Charlet J.
europepmc +1 more source
Exploiters-Based Knowledge Extraction in Object-Oriented Knowledge\n Representation [PDF]
, 2015 Dmytro Terletskyi
openalex +1 more source
Categories Name for Highly Abstract Ontologies: Limitations and Recommendations
Advances in Knowledge RepresentationWhat’s in a name? This paper highlights some limitations of existing category terms for highly abstract ontologies (and similar types of abstraction models), and proposes recommendations.
Robert Rovetto
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source