Results 131 to 140 of about 3,257,416 (300)

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

Desafios para Geração do Identificador Único de Imóveis Rurais e Urbanos no Cadastro Imobiliário Brasileiro (CIB)

open access: yesAdvances in Knowledge Representation
A Lei Complementar (LC) nº 214, de 16 de janeiro de 2025, ao regulamentar a Reforma Tributária sobre o Consumo (RTC), estabeleceu que todos os imóveis rurais e urbanos deverão ser inscritos, sob identificação única, no Cadastro Imobiliário Brasileiro ...
Stenio Max Lacerda   +3 more
doaj  

Representation Learning for Person or Entity-centric Knowledge Graphs: An Application in Healthcare [PDF]

open access: green, 2023
Christos Theodoropoulos   +3 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

Knowledge‐based representation: Patient engagement in drug development

open access: yesHealth Expectations
Introduction Recently, different actors have intensified their efforts to make drug development more participatory. They have produced many frameworks, tools and dedicated fora, where patients are portrayed as relevant stakeholders to be involved ...
Claudia Egher, Olga Zvonareva
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

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