Results 121 to 130 of about 733,474 (306)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Mereocausality & Causal Mereotopology: A New Concept

open access: yesAdvances in Knowledge Representation
. How is causality/causation associated with parthood? And do parts and their whole interact in distinct causal manners? I introduce a novel concept I call ‘mereocausality’ and its cognates, merging two foundational topics in theoretical and practical ...
Robert Rovetto
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Modelagem semântica para representação de instrumentos musicais:

open access: yesAdvances in Knowledge Representation
Investiga-se, de forma analítica e comparativa, a possibilidade de modelagem semântica para representação de instrumentos musicais, propondo ampliação da interoperabilidade semântica do Museu Virtual de Instrumentos Musicais (MVIM).
Durval Vieira Pereira   +2 more
doaj  

ARLO: Another Representation Language Offer

open access: yes, 1986
This paper describes ARLO, a representation language loosely modelled after Greiner and Lenant's RLL-1. ARLO is a structure-based representation language for describing structure-based representation languages, including itself.
Haase, Kenneth W., Jr.
core  

A Representation Formalism for Supporting Reuse of Software Engineering Knowledge

open access: yes, 2022
S.61-70 : Ill., Lit.To transfer innovative software technologies into practice and to continuously improve the software quality and productivity, software-related knowledge should be reused.
Tautz, C., Gresse von Wangenheim, C.
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

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