Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Advances in Knowledge Representation. In this article, we continue the study and definition of a class of ontologies known as “epistemic” by laying the foundations for a foundational epistemic ontology called EFO (for Epistemic Foundational Ontology).
Gilles Kassel
doaj
Knowledge Representation and Management: Interest in New Solutions for Ontology Curation. [PDF]
Yearb Med Inform, 2021 Dhombres F +2 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Foundations Matter: The Role of Top-Level Ontologies in Knowledge Representation
Advances in Knowledge Representation...
Fernanda Farinelli
doaj
The Sickle Cell Disease Ontology: recent development and expansion of the universal sickle cell knowledge representation. [PDF]
Database (Oxford), 2022 Mazandu GK +4 more
europepmc +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Especificação e validação de requisitos funcionais para a Ontologia Pinakes no domínio bibliográfico
Advances in Knowledge RepresentationEste artigo apresenta o processo de especificação e validação dos requisitos funcionais da Ontologia Pinakes, desenvolvida para integrar os serviços bibliográficos do Instituto Brasileiro de Informação em Ciência e Tecnologia (Ibict), incluindo o ...
Ana Carolina Simionato Arakaki +5 more
doaj
Knowledge Representation for Multi-Scale Physiology Route Modeling. [PDF]
Front Neuroinform, 2021 Kokash N, de Bono B.
europepmc +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source