Results 41 to 50 of about 8,064,818 (293)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Spaced scenario demonstrations improve knowledge and confidence in Pediatric acute illness management.

Frontiers in Pediatrics, 2014
ObjectivesNationally accredited simulation courses such as Advance Paediatric Life Support (APLS) and Pediatric Advance life support (PALS) are recommended for health care professionals (HCPs) at 2 yearly intervals as a minimum requirement, despite ...
Rahul eOjha, Anthony eLiu, Bernard Linton Champion, Emily eHibbert, Ralph Kay Heinrich Nanan   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Smartphone Appropriation and Knowledge Retention in Technology-Mediated Learning [PDF]

, 2021
Digitization of learning activities has introduced some notable improvements as well as some significant knowledge retention impairments. Extant theories of knowledge retention are dominated by instrumental and cognitive approaches.
Wiredu, Gamel O, Dwomor, Daniel
core   +2 more sources

Knowledge Retention of Undergraduate Medical Students in Regional Anatomy Following a One-Month Gross Anatomy Course Setting

Education Sciences
Background: In the achievement of optimal learning outcomes, knowledge retention presents a major concern for medical students and educators. Practical dissection courses facilitate the consolidation of knowledge of anatomy. Previously, it was shown that
Veronica Antipova, Martin Siwetz, Maren Engelhardt, Franz A. Fellner, Simone Manhal, Julian F. Niedermair, Benjamin Ondruschka, Amélie J. Poilliot, Andreas Wree, Niels Hammer   +9 more
doaj   +1 more source

Students’ Perception on Problem-based and Limerick-based Learning Methods: A Mixed-method Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Medical education continuously explores innovative teaching methods to enhance student engagement, critical thinking, and knowledge retention.
Asitava Deb Roy, Ka Narayan, Mala Mukherjee, Shivasakthy Manivasakan, Aarushi Khajuria, Veena Jyoti, Himel Mondal   +6 more
doaj   +1 more source