Results 101 to 110 of about 2,109,221 (325)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Knowledge synthesis: Animal health and welfare in organic pig production - Final Report COREPIG [PDF]

, 2011
This report reviews the available information on the welfare of pigs when maintained according to organic standards in Europe. It begins by overviewing the populations of organic pigs in different countries at the time of writing (2007), the organic ...
Bochicchio, David, Bonde, Marianne, Edwards, Sandra, Früh, Barbara, Hegelund, Lene, Heinonen, Mari, Leeb, Christine, Lindgren, Kristina, Lubac, Stanislas, Maupertuis, F., Mejer, Helena, Prunier, Armelle, Roepstorff, Allan, Rousing, Tine, Sundrum, Albert, Sundrum, Albert, Werne, Steffen, Wiberg, Sophia   +17 more
core  

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Citizen Science Approach for Searching and Curating Literature on the Effects of Spaceflight on Cardiovascular Outcomes in Rodents and Humans

Citizen Science: Theory and Practice
The spaceflight environment affects the structure and function of the cardiovascular system, including fluid redistribution, alterations in blood pressure, and changes in cardiac output.
Mattias Neset, Ryan T. Scott, S. Anand Narayanan, Svetlana V. Komarova   +3 more
doaj   +1 more source

Relation of Vegetarian Dietary Patterns With Major Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Frontiers in Nutrition, 2019
Background: Vegetarian dietary patterns are recommended for cardiovascular disease (CVD) prevention and management due to their favorable effects on cardiometabolic risk factors, however, the role of vegetarian dietary patterns in CVD incidence and ...
Andrea J. Glenn, Andrea J. Glenn, Andrea J. Glenn, Effie Viguiliouk, Effie Viguiliouk, Effie Viguiliouk, Maxine Seider, Maxine Seider, Maxine Seider, Beatrice A. Boucher, Tauseef A. Khan, Tauseef A. Khan, Tauseef A. Khan, Sonia Blanco Mejia, Sonia Blanco Mejia, Sonia Blanco Mejia, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, Hana Kahleová, Hana Kahleová, Dario Rahelić, Dario Rahelić, Jordi Salas-Salvadó, Jordi Salas-Salvadó, Cyril W. C. Kendall, Cyril W. C. Kendall, Cyril W. C. Kendall, Cyril W. C. Kendall, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper   +36 more
doaj   +1 more source

Contribution to the Knowledge of the Antarctic Ice Sheet: A Synthesis of Glaciological Measurements in Terre Adélie [PDF]

, 1962
C. Lorius
openalex   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source