Results 81 to 90 of about 10,034,810 (276)

Genomic Information for Clinicians in the Electronic Health Record: Lessons Learned From the Clinical Genome Resource Project and the Electronic Medical Records and Genomics Network

Frontiers in Genetics, 2019
Genomic knowledge is being translated into clinical care. To fully realize the value, it is critical to place credible information in the hands of clinicians in time to support clinical decision making.
Marc S. Williams, Casey Overby Taylor, Casey Overby Taylor, Nephi A. Walton, Scott R. Goehringer, Samuel Aronson, Robert R. Freimuth, Luke V. Rasmussen, Eric S. Hall, Cynthia A. Prows, Wendy K. Chung, Alexander Fedotov, Jordan Nestor, Chunhua Weng, Robb K. Rowley, Georgia L. Wiesner, Gail P. Jarvik, Guilherme Del Fiol   +17 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Unveiling and advancing grassland degradation research using a BERTopic modelling approach

Journal of Integrative Agriculture
Grassland degradation presents overwhelming challenges to biodiversity, ecosystem services, and the socio-economic sustainability of dependent communities. However, a comprehensive synthesis of global knowledge on the frontiers and key areas of grassland
Tong Li, Lizhen Cui, Yu Wu, Rajiv Pandey, Hongdou Liu, Junfu Dong, Weijin Wang, Zhihong Xu, Xiufang Song, Yanbin Hao, Xiaoyong Cui, Jianqing Du, Xuefu Zhang, Yanfen Wang   +13 more
doaj   +1 more source

Synthesis from Knowledge-Based Specifications

CoRR, 2013
In program synthesis, we transform a specification into a program that is guaranteed to satisfy the specification. In synthesis of reactive systems, the environment in which the program operates may behave nondeterministically, e.g., by generating different sequences of inputs in different runs of the system.
Ron van der Meyden, Moshe Y. Vardi
openaire   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises

GeoHealth
Understanding how the environment shapes our mental and cognitive health is imperative to support efforts that promote healthy and sustainable living conditions.
Lars Ratjen, Emily Goddard, Elise B. Gilcher, Breanna K. Nguyen, Mariana Kelley, Hannah S. Feldman, Kelechi Akalaonu, Kate Nyhan, Andreas Backhaus, Miren López Lascurain, Nora E. Wyrtzen, Sara Smiley Smith, Maya Prabhu, Sarah R. Lowe, Kai Chen, Julie B. Zimmerman, Paul T. Anastas   +16 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source