Results 71 to 80 of about 10,034,810 (276)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Knowledge synthesis research: a bibliometric analysis

Journal of Clinical Epidemiology, 2016
The purpose of this article is to describe the volume and attributes of original research available in PubMed on emerging knowledge synthesis methods (excluding traditional systematic reviews) published by researchers.Bibliometric analysis.Six-hundred eight studies related to the topic of knowledge synthesis methods were analyzed.
Perrier, Laure, Lightfoot, David, Kealey, M Ryan, Straus, Sharon E, Tricco, Andrea C   +4 more
openaire   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Global environmental knowledge synthesis: What’s in it for national action?

Sustainability: Science, Practice, & Policy
Global environmental assessments (GEAs) support international environmental governance by synthesizing state-of-the-art scientific knowledge. Increasingly, they also articulate solutions to environmental risks.
Salla Rantala, Jason Jabbour, Juuli Närhi   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Relation of Vegetarian Dietary Patterns With Major Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Frontiers in Nutrition, 2019
Background: Vegetarian dietary patterns are recommended for cardiovascular disease (CVD) prevention and management due to their favorable effects on cardiometabolic risk factors, however, the role of vegetarian dietary patterns in CVD incidence and ...
Andrea J. Glenn, Andrea J. Glenn, Andrea J. Glenn, Effie Viguiliouk, Effie Viguiliouk, Effie Viguiliouk, Maxine Seider, Maxine Seider, Maxine Seider, Beatrice A. Boucher, Tauseef A. Khan, Tauseef A. Khan, Tauseef A. Khan, Sonia Blanco Mejia, Sonia Blanco Mejia, Sonia Blanco Mejia, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, David J. A. Jenkins, Hana Kahleová, Hana Kahleová, Dario Rahelić, Dario Rahelić, Jordi Salas-Salvadó, Jordi Salas-Salvadó, Cyril W. C. Kendall, Cyril W. C. Kendall, Cyril W. C. Kendall, Cyril W. C. Kendall, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper, John L. Sievenpiper   +36 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Citizen Science Approach for Searching and Curating Literature on the Effects of Spaceflight on Cardiovascular Outcomes in Rodents and Humans

Citizen Science: Theory and Practice
The spaceflight environment affects the structure and function of the cardiovascular system, including fluid redistribution, alterations in blood pressure, and changes in cardiac output.
Mattias Neset, Ryan T. Scott, S. Anand Narayanan, Svetlana V. Komarova   +3 more
doaj   +1 more source