Results 51 to 60 of about 10,034,810 (276)

Regional Strategic Analysis and Knowledge Support System (ReSAKSS)

, 2020
Regional strategic analysis and knowledge support system (ReSAKSS) is a Africa-focused database nodes that compile, analyze, and disseminate data, information, and tools to help design, implement, monitor, and evaluate rural development strategies.Non ...
Regional Strategic Analysis and Knowledge Support System (ReSAKSS)
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

COVID-19 impact on AMR: a rapid scoping review, equity analysis and evidence gap map study

BMJ Global Health
Introduction The COVID-19 pandemic is expected to have impacted many drivers of antimicrobial resistance (AMR) and compounded existing societal and health inequities.
Susan Rogers Van Katwyk, Mathieu J P Poirier, Becky Skidmore, Ebiowei Samuel F Orubu, Kawsari Abdullah, Fiona Emdin, Kayla Strong, Nicole Shaver, Gideon Asamoah, Emilie Chan   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Screening for depression in children and adolescents in primary care or non-mental health settings: a systematic review update

Systematic Reviews
Background The transition from childhood to adolescence is associated with an increase in rates of some psychiatric disorders, including major depressive disorder, a debilitating mood disorder.
Andrew Beck, Nicole Dryburgh, Alexandria Bennett, Nicole Shaver, Leila Esmaeilisaraji, Becky Skidmore, Scott Patten, Heather Bragg, Ian Colman, Gary S. Goldfield, Stuart Gordon Nicholls, Kathleen Pajer, Robert Meeder, Priya Vasa, Beverley J. Shea, Melissa Brouwers, Julian Little, David Moher   +17 more
doaj   +1 more source

Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence

Health Promotion and Chronic Disease Prevention in Canada
IntroductionWe investigated the prevalence of new or persistent manifestations experienced by COVID-19 survivors at 3 or more months after their initial infection, collectively known as post-COVID-19 condition (PCC ...
Mohamed Kadry Taher, Talia Salzman, Allyson Banal, Kate Morissette, Francesca R. Domingo, Angela M. Cheung, Curtis L. Cooper, Laura Boland, Alexandra M. Zuckermann, Muhammad A. Mullah, Claudie Laprise, Roberto Colonna, Ayan Hashi, Prinon Rahman, Erin Collins, Tricia Corrin, Lisa A. Waddell, Jason E. Pagaduan, Rukshanda Ahmad, Alejandra P. Jaramillo Garcia   +19 more
doaj   +1 more source

Can ‘digital natives’ be ‘strangers’ to digital technologies? An analytical reflection

Inkanyiso, 2020
Although a plethora of extant literature categorises them as natives in the digital world, it has been counter-argued that a considerable group of young people cannot be designated as ‘digital natives’.
Theodora D. Adjin-Tettey
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source