Results 41 to 50 of about 10,034,810 (276)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Leveraging Existing Services to Support Evidence Synthesis Researchers Outside of the Health Sciences

Journal of Graduate Librarianship, 2023
The author presents a case study for the development of an evidence synthesis service serving researchers outside of the health sciences at a large academic library. The purpose of this project was to highlight the importance of integrating existing core
Elizabeth Kline
doaj   +1 more source

An inclusive and diverse governance structure of the strategy for patient-oriented research (SPOR) Evidence Alliance

FACETS, 2022
The Strategy for Patient Oriented Research (SPOR) Evidence Alliance is a research initiative in Canada whose mission is to promote the synthesis, dissemination, and integration of research results into health care and public health decision-making and ...
Carole Lunny, Wasifa Zarin, Sabrina Chaudhry, Sonia M. Thomas, Annie LeBlanc, Sophie Desroches, Tanya Horsley, Heather Colquhoun, Priscille-Nice Sanon, Minnie Downey, Zahra Goodarzi, Nancy N. Baxter, Kelly English, Elliot PausJenssen, Shanon McQuitty, Linda Wilhelm, Annette McKinnon, Alison M. Hoens, Linda C. Li, Fiona Clement, Janet A. Curran, Ahmed M. Abou-Setta, Christina Godfrey, David Moher, Pertice Moffitt, Jennifer Walker, Janet Jull, Cheryl Koehn, Wanrudee Isaranuwatchai, Sharon E. Straus, Andrea C. Tricco   +30 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effectiveness of e-cigarettes as a stop smoking intervention in adults: a systematic review

Systematic Reviews
Background This systematic review aims to identify the benefits and harms of electronic cigarettes (e-cigarettes) as a smoking cessation aid in adults (aged ≥ 18 years) and to inform the development of the Canadian Task Force on Preventive Health Care’s (
Niyati Vyas, Alexandria Bennett, Candyce Hamel, Andrew Beck, Micere Thuku, Mona Hersi, Nicole Shaver, Becky Skidmore, Brian Hutton, Douglas Manuel, Matt Morrow, Smita Pakhale, Justin Presseau, Beverley J. Shea, Julian Little, David Moher, Adrienne Stevens   +16 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Challenges and Facilitators for Physicians and Medical Schools to Promote Social Accountability in Rural Communities: A Scoping Review and Thematic Analysis

Journal of Medical Education and Curricular Development
Background Social accountability aligns the health demands and priorities of the community and the commitment of medical schools. Existing literature has proposed contextually distinctive interventions encompassing geographical initiatives, institutions ...
Aghna Wasim, Ali Abud, Yihan Wang, Ehsan Tavakoli, Athena Moreno-Gris, Samar Joshi, Arthur Wang, Angela Neasadurai, Nikki Shaw   +8 more
doaj   +1 more source

Infection prevention and control measures for Ebola and Marburg disease: a series of rapid reviews

BMJ Open
Objectives An evidence synthesis informed the 2023 WHO infection prevention and control (IPC) guideline for Ebola disease (EBOD) and Marburg disease (MARD).Design A series of rapid reviews addressed 14 key questions (KQs) related to IPC measures for EBOD
Sharmistha Mishra, Andrea C Tricco, Becky Skidmore, Ba Pham, Julian Little, Melissa Brouwers, Adrienne K Chan, Andrew Beck, Devika Dixit, Alexandria Bennett, Gordon V Cormack, Maura R Grossman, Erin Collins, Victoria Willet, April Baller, Nicole Shaver, Niyati Vyas   +16 more
doaj   +1 more source