Results 91 to 100 of about 521,209 (310)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Establishing Effective Patient Engagement Through a Terms of Reference to Foster Inclusivity and Empowerment in Research: Example From a Healthcare Transition Quality Indicators Project

Health Expectations
Introduction Patient engagement in research aims to foster meaningful partnerships, integrating patient experiences into the research process. This paper describes the development of a Terms of Reference (ToR) to support these meaningful partnerships ...
Sarah E. P. Munce, Tomisin John, Dorothy Luong, Sarah Mooney, Lisa Stromquist, Kyle Chambers, Marilyn Crabtree, Sanober Diaz, Gina Dimitropoulos, Megan Henze, Amanda Higgins, Elaine Li, Samadhi Mora Severino, Melanie Penner, Jacklynn Pidduck, Michelle Wan, Laura Williams, Darryl Yates, Alene Toulany   +18 more
doaj   +1 more source

Knowledge Translation in Oncology. A Case Study [PDF]

, 2020
Knowledge translation (KT) is the ability to make knowledge accessible to different stakeholders by translating it into various contexts. Translating knowledge is particularly crucial in the healthcare sector, which is currently under significant ...
Biancuzzi, Helena, Lorenzo Cobianchi, Luca Miceli, Maurizio Massaro, Amelia Barcellini, Barcellini, Amelia, Miceli, Luca, Massaro, Maurizio, Cobianchi, Lorenzo, Francesca Dal Mas, Helena Biancuzzi, Dal Mas, Francesca   +11 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Living Educational Theory of Knowledge Translation: Improving Practice, Influencing Learners, and Contributing to the Professional Knowledge Base [PDF]

, 2013
This paper captured our joint journey to create a living educational theory of knowledge translation (KT). The failure to translate research knowledge to practice is identified as a significant issue in the nursing profession.
Johnston, Jan, Vickers-Manzin, Jen
core   +1 more source

Teleworking and collaborative work environments in translation training [PDF]

, 2009
The professional translation work is highly influenced by new communication opportunities, reason why teleworking must occupy its rightful place in translator training at tertiary level.
Muñoz-Martín, Ricardo, Castro-Prieto, María Rosa, Olvera-Lobo, María-Dolores, Robinson, Bryan, Murillo-Melero, Miguel, Conde-Ruano, Tomás, Olvera-Lobo, María Dolores, Senso, Jose A., Quero-Gervilla, Enrique, Muñoz-Raya, Eva   +9 more
core   +1 more source

The ideology of translation vs translation procedures [PDF]

, 2020
Translation plays an important role in the transfer of knowledge between cultures, languages ​​and nations different. As an activity to transfer the message or purpose contained in one language into another language appropriately and naturally ...
Ryan, A. (Anne), Ryan, Anne
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Patients’ experiences while undergoing high-intensity gait training during inpatient stroke rehabilitation: a qualitative study

BMC Health Services Research
Background High-intensity gait training is an evidence-based intervention for improving walking outcomes after stroke, but little is known about how patients experience this intervention during inpatient rehabilitation. Understanding patient perspectives
Jennifer L. Moore, Julia A. Mbalilaki, Stein A. Rimehaug, Siri N. Tveitan, Anne-Margrethe Linnestad, Pia Krøll, Simen Lundberg, Marianne Molle, Ingvild Lilleheie   +8 more
doaj   +1 more source