Results 81 to 90 of about 521,209 (310)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Knowledge translation is everybody's business [PDF]

Journal of Controlled Release, 2021
Successful application of research outcomes into routine healthcare practice rarely occurs as an immediate result of their publication [1]. A much-cited example is the 40-year delay in the British Navy’s adoption of vitamin C for the prevention of scurvy, despite substantial evidence of benefit from the first ever controlled trial conducted by James ...
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

Biology, 2020
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert, María Morán, Patricia de la Cruz-Ojeda, Jordi Muntané, Tabea Wiedmer, Nadezda Apostolova, Sharon L. McKenna, Guillermo Velasco, Walter Balduini, Leopold Eckhart, Bassam Janji, Belém Sampaio-Marques, Paula Ludovico, Eva Žerovnik, Rupert Langer, Aurel Perren, Nikolai Engedal, Mario P. Tschan   +17 more
doaj   +1 more source

What is Translation? [PDF]

, 2020
As the translation scholar Michael Cronin states, “if we want a world that values diversity of perspective over the certainty of singular belief, a world where many voices balance the privileged few, then translators must be part of the dialogue” (Eco ...
Johnson, Amber C
core   +1 more source

Knowledge Distillation for Sustainable Neural Machine Translation [PDF]

, 2022
Knowledge distillation (KD) can be used to reduce model size and training time, without significant loss in performance. However, the process of distilling knowledge requires translation of sizeable data sets, and the translation is usually performed ...
Superbo, Riccardo, Jooste, Wandri, Way, Andy, Haque, Rejwanul   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Perceptions of Pediatric Nephrologists regarding Timing of Dialysis Initiation in Children in Canada

Canadian Journal of Kidney Health and Disease, 2016
Background: Significant practice variation exists in Canada with respect to timing of dialysis initiation in children. In the absence of evidence to guide practice, physicians' perceptions may significantly influence decision-making.
Jeremy A. Saban, Michael Zappitelli, Susan M. Samuel, Manish M. Sood, R. Todd Alexander, Steven Arora, Robin L. Erickson, Kristine Kroeker, Braden J. Manns, Allison B. Dart   +9 more
doaj   +1 more source

Pregnant women’s views on how to promote the use of a decision aid for Down syndrome prenatal screening: a theory-informed qualitative study

BMC Health Services Research, 2018
Background For pregnant women and their partners, the decision to undergo Down syndrome prenatal screening is difficult. Patient decision aids (PtDA) can help them make an informed decision.
Titilayo Tatiana Agbadjé, Matthew Menear, Michèle Dugas, Marie-Pierre Gagnon, Samira Abbasgholizadeh Rahimi, Hubert Robitaille, Anik M. C. Giguère, François Rousseau, Brenda J. Wilson, France Légaré   +9 more
doaj   +1 more source

The Knowledge Broker's “Fit” in the World of Knowledge Translation [PDF]

Physiotherapy Canada, 2014
Evidence-informed practice (EIP) is a challenge. Success requires facilitators at multiple levels: the individual clinician (e.g., skills for accessing and appraising literature); the organization (e.g., providing resources for training and protected time); professional and regulatory bodies (e.g., need for consensus on standards of practice and ...
Alison M, Hoens, Linda C, Li
openaire   +2 more sources