Results 71 to 80 of about 8,134,950 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Guidance for using artificial intelligence for title and abstract screening while conducting knowledge syntheses

BMC Medical Research Methodology, 2021
Background Systematic reviews are the cornerstone of evidence-based medicine. However, systematic reviews are time consuming and there is growing demand to produce evidence more quickly, while maintaining robust methods.
Candyce Hamel, Mona Hersi, Shannon E. Kelly, Andrea C. Tricco, Sharon Straus, George Wells, Ba’ Pham, Brian Hutton   +7 more
doaj   +1 more source

Safety and effectiveness of dose-sparing strategies for intramuscular seasonal influenza vaccine: a rapid scoping review

BMJ Open, 2021
Background The objective of this rapid scoping review was to identify studies of dose-sparing strategies for administration of intramuscular seasonal influenza vaccines in healthy individuals of all ages.Methods Comprehensive literature searches were ...
Sharon E Straus, Jesmin Antony, Andrea C Tricco, Carole Lunny, Patricia Rios, Chantal Williams, Naveeta Ramkissoon   +6 more
doaj   +1 more source

Balancing exploration and exploitation in transferring research into practice : a comparison of five knowledge translation entity archetypes [PDF]

, 2013
Background: Translating knowledge from research into clinical practice has emerged as a practice of increasing importance. This has led to the creation of new organizational entities designed to bridge knowledge between research and practice.
Girts Racko, Oborn, Eivor, Karl Prince, Eivor Oborn, Prince, Karl, Racko, Girts, Michael Barrett, Barrett, Michael   +7 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Knowledge translation: translating research into policy and practice [PDF]

Revista Gaúcha de Enfermagem, 2015
Objective: This paper provides a theoretical-reflective study of knowledge translation concepts and their implementation processes for using research evidence in policy and practice.Results: The process of translating research into practice is iterative and dynamic, with fluid boundaries between knowledge creation and action development.
Oelke, Nelly Donszelmann, Lima, Maria Alice Dias da Silva, Acosta, Aline Marques   +2 more
openaire   +4 more sources

Knowledge translation is everybody's business [PDF]

Journal of Controlled Release, 2021
Successful application of research outcomes into routine healthcare practice rarely occurs as an immediate result of their publication [1]. A much-cited example is the 40-year delay in the British Navy’s adoption of vitamin C for the prevention of scurvy, despite substantial evidence of benefit from the first ever controlled trial conducted by James ...
openaire   +4 more sources

Attitudes towards indirect translation in Finland and translators’ strategies: Compilative and collaborative translation [PDF]

, 2022
In Finland, indirect translation (ITr) played an important role as early as the sixteenth century in the formation of literary language. In the late nineteenth century, the first signs of critics condemning ITr began to appear.
Ivaska Laura, Paloposki Outi
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

Biology, 2020
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert, María Morán, Patricia de la Cruz-Ojeda, Jordi Muntané, Tabea Wiedmer, Nadezda Apostolova, Sharon L. McKenna, Guillermo Velasco, Walter Balduini, Leopold Eckhart, Bassam Janji, Belém Sampaio-Marques, Paula Ludovico, Eva Žerovnik, Rupert Langer, Aurel Perren, Nikolai Engedal, Mario P. Tschan   +17 more
doaj   +1 more source