Results 111 to 120 of about 497,473 (309)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A Connectionist Model of Spatial Knowledge Acquisition in a Virtual Environment

, 2013
MLIRUM'03, Second Workshop on Machine Learning, Information Retrieval and User Modelling, at 9th International Conference on User Modelling, June 22nd-26th, Pittsburgh, PA, USAThis paper proposes the use of neural networks as a tool for studying ...
O'Hare, G. M. P. (Greg M. P.), Sas, Corina, Reilly, Ronan, O\u27Hare, G. M. P. (Greg M. P.)   +3 more
core  

Transforming User Knowledge into Archival Knowledge

D-Lib Magazine, 2016
Kärberg, Tarvo, Saarevet, Koit
openaire   +3 more sources

Users’ understanding of medical knowledge in general practice

Social Science & Medicine, 2002
Much emphasis is now being placed on the quality of medical care, and various ways are being developed to assess the medical knowledge of general practitioners. It is increasingly recognised that the users perspective on health care is important, and that the views of health care professionals do not and cannot represent patients' views.
Chapple, Alison, Campbell, Stephen, Rogers, Anne, Roland, Martin   +3 more
openaire   +4 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The User Centred Knowledge Model - t-UCK

, 2008
In knowledge engineering, modelling knowledge is the process of structuring knowledge before implementation. A crucial part of system development depends on the acquiring and structuring, since the quality of system’s contents is of decisive importance ...
Håkansson, Anne,
core   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

End user development: What influences the relationship between satisfaction with tools and satisfaction with applications

, 2001
This study explored the possible role of four factors in the relationship between end user developers’ perceptions of their applications and their perceptions of the tools used to create them.
Loh, G., McGill, T.J., Wong, L., Seow, H.H., Lee, C.   +4 more
core  

Beyond the prompt: The Role of User Behavior in Shaping AI-misalignment and Societal Knowledge

Technology and Regulation
This research paper explores the concept of AI-misalignment, differentiating between perspectives of AI model designers and users. It delves into the notion of user-centric AI misalignment, breaking it down into three categories: user responsibility ...
Morraya Benhammou
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source