Results 91 to 100 of about 497,473 (309)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Detecting real user tasks by training on laboratory contextual attention metadata [PDF]

open access: yes, 2009
Detecting the current task of a user is essential for providing her with contextualized and personalized support, and using Contextual Attention Metadata (CAM) can help doing so.
Lindstaedt, Stefanie N.   +2 more
core  

Efficient user scheduling in mmWave networks: leveraging knowledge transfer with channel knowledge map

open access: yesDigital Communications and Networks
This paper proposes a Deep Reinforcement Learning (DRL) algorithm for user scheduling in Millimeter Wave (mmWave) networks, which utilizes Channel Knowledge Map (CKM) for knowledge transfer to enhance the learning of scheduling strategies.
Chunlong He, Peihong He, Xingquan Li
doaj   +1 more source

Knowledge construction by users

open access: yesJournal of Documentation, 2017
PurposeThe purpose of this paper is to develop a content analysis framework and from that derive a process model of knowledge construction in the context of virtual product user communities, organization sponsored online forums where product users collaboratively construct knowledge to solve their technical problems.Design/methodology/approachThe study
Xuguang Li   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Spreadsheet knowledge: An exploratory study

open access: yes, 2001
Spreadsheets are the most commonly used tool for end user development of applications, and organizations depend heavily upon them for decision making. This paper reports on a study to investigate the role of spreadsheet knowledge in the successful use of
Dixon, M.W., McGill, T.J.
core  

Embrace thy users Practices of user knowledge utilization in innovation

open access: yes, 2019
User knowledge is an inherent part of innovation that organizations strive to include systematically at different stages of their innovation process. However, utilizing user knowledge in innovation processes is a complex phenomenon.
Benker, Andreas
openaire   +5 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Knowledge Work: Knowledge Worker Productivity, Collaboration and User Support. [PDF]

open access: yesJ. Univers. Comput. Sci., 2011
Knowledge Work: Knowledge Worker Productivity, Collaboration and User ...
Granitzer,Michael, Lindstaedt,Stefanie
openaire   +2 more sources

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