Results 1 to 10 of about 1,445 (152)

The gut microbiome in konzo [PDF]

Nature Communications, 2021
Here, using metagenomic profiling in 180 individuals from the Democratic Republic of the Congo, the authors find associations between the gut microbiome and konzo, a neurodegenerative disease that mostly affects children and is caused by the consumption ...
Matthew S. Bramble, Neerja Vashist, Arthur Ko, Sambhawa Priya, Céleste Musasa, Alban Mathieu, D’ Andre Spencer, Michel Lupamba Kasendue, Patrick Mamona Dilufwasayo, Kevin Karume, Joanna Nsibu, Hans Manya, Mary N. A. Uy, Brian Colwell, Michael Boivin, J. P. Banae Mayambu, Daniel Okitundu, Arnaud Droit, Dieudonné Mumba Ngoyi, Ran Blekhman, Desire Tshala-Katumbay, Eric Vilain   +21 more
doaj   +7 more sources

Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis [PDF]

The Lancet Global Health, 2017
Background: Konzo is an irreversible upper-motor neuron disorder affecting children dependent on bitter cassava for food. The neurocognitive ability of children with konzo over time has yet to be fully documented.
Prof Michael J Boivin, PhD, Daniel Okitundu, MD, Bumoko Makila-Mabe, MD, Marie-Therese Sombo, MD, Prof Dieudonne Mumba, PhD, Prof Alla Sikorskii, PhD, Prof Banea Mayambu, PhD, Prof Desire Tshala-Katumbay, PhD   +7 more
doaj   +4 more sources

Glutathione peroxidase 3 is a potential biomarker for konzo [PDF]

Nature Communications
Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the world’s poorest children and women of childbearing ages across regions of sub-Saharan Africa.
Matthew S. Bramble, Victor Fourcassié, Neerja Vashist, Florence Roux-Dalvai, Yun Zhou, Guy Bumoko, Michel Lupamba Kasendue, D’Andre Spencer, Hilaire Musasa Hanshi-Hatuhu, Vincent Kambale-Mastaki, Rafael Vincent M. Manalo, Aliyah Mohammed, David R. McIlwain, Gary Cunningham, Marshall Summar, Michael J. Boivin, Ljubica Caldovic, Eric Vilain, Dieudonne Mumba-Ngoyi, Desire Tshala-Katumbay, Arnaud Droit   +20 more
doaj   +6 more sources

Cassava, konzo, and neurotoxicity [PDF]

The Lancet Global Health, 2017
Cassava (Manihot esculenta) forms part of the staple diet for more than 600 million people across the world, particularly those that live in poverty and remote areas where food security is poor.1 The plant grows in poor soil and is relatively drought resistant; the tubers are rich in carbohydrates and the leaves contain some protein.
Charles R Newton
doaj   +6 more sources

Konzo prevention in six villages in the DRC and the dependence of konzo prevalence on cyanide intake and malnutrition [PDF]

Toxicology Reports, 2015
Six villages in Boko Health Zone, Bandundu Province, DRC, were studied with 4588 people, 144 konzo cases and konzo prevalences of 2.0–5.2%. Konzo incidence is increasing rapidly in this area. Food consumption scores were obtained from the households with
J.P. Banea, J. Howard Bradbury, C. Mandombi, D. Nahimana, Ian C. Denton, Matthew P. Foster, N. Kuwa, D. Tshala Katumbay   +7 more
doaj   +5 more sources

When knowledge is not enough: barriers to recommended cassava processing in resource-constrained Kwango, Democratic Republic of Congo [PDF]

Journal of Public Health in Africa, 2023
Background: Despite interventions to provide knowledge and improve bitter cassava processing in the Democratic Republic of Congo (DRC), cassava processing is sub-optimal.
Gisele Bokundabi, Lyn Haskins, Christiane Horwood, Césarine Kuwa, Paulin B. Mutombo, Vaughn M. John, Mala A. Mapatano, Jean-Pierre Banea   +7 more
doaj   +2 more sources

Research on motor neuron diseases konzo and neurolathyrism: trends from 1990 to 2010. [PDF]

PLoS Neglected Tropical Diseases, 2012
Konzo (caused by consumption of improperly processed cassava, Manihot esculenta) and neurolathyrism (caused by prolonged overconsumption of grass pea, Lathyrus sativus) are two distinct non-infectious upper motor neurone diseases with identical clinical ...
Delphin Diasolua Ngudi, Yu-Haey Kuo, Marc Van Montagu, Fernand Lambein   +3 more
doaj   +5 more sources

DNA methylation patterns associated with konzo in Sub-Saharan Africa. [PDF]

Clin Epigenetics, 2022
AbstractKonzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exposure to cyanogenic bitter cassava. The molecular mechanisms underlying the development of konzo remain largely unknown. Here, through an
Kocher K, Bhattacharya S, Bramble MS, Okitundu-Luwa D, Ngoyi DM, Tshala-Katumbay D, Vilain E.   +6 more
europepmc   +5 more sources

Konzo outbreak in the Western Province of Zambia. [PDF]

Neurology, 2020
To identify the etiology of an outbreak of spastic paraparesis among women and children in the Western Province of Zambia suspected to be konzo.We conducted an outbreak investigation of individuals from Mongu District, Western Province, Zambia, who previously developed lower extremity weakness.
Siddiqi OK, Kapina M, Kumar R, Ngomah Moraes A, Kabwe P, Mazaba ML, Hachaambwa L, Ng'uni NM, Chikoti PC, Morel-Espinosa M, Jarrett JM, Baggett HC, Chizema-Kawesha E.   +12 more
europepmc   +4 more sources

Climate Regimes, El Nino-Southern Oscillation and Konzo Epidemics [PDF]

Frontiers in Environmental Science, 2015
Epidemics of konzo have occurred during severe droughts in parts of east, central, and southern Africa since the 1920s. Occurrence is attributed to exposure to cyanide from poorly processed cassava foods, the sole source of calories when other food crops
Olusegun Steven Ayodele Oluwole
doaj   +2 more sources