Results 161 to 170 of about 1,823 (200)

New insight into the molecular etiopathogenesis of konzo: Cyanate could be a plausible neurotoxin contributing to konzo, contrary to thiocyanate.

NeuroToxicology
INTRODUCTION Chronic cassava-derived cyanide poisoning is associated with the appearance of konzo, a tropical spastic paraparesis due to selective upper motor neuron damage.
Marius Baguma, S. Kessels, Virginie Bito, B. Brône, A. Triller, S. Maynard, Pascal Legendre, Jean-Michel Rigo, Hervé Le Corronc, J. Chabwine   +9 more
semanticscholar   +4 more sources

Neuro-ophthalmologic manifestations of konzo

Environmental Toxicology and Pharmacology, 2005
Konzo is a permanent spastic paraparesis of acute onset attributed to the effect of cyanogenic compounds from insufficiently processed bitter cassava in combination with low protein intake. In all studies of konzo, ophthalmologic complaints have been presented but only recently systematic studies of the neuro-ophthalmologic disturbances in konzo have ...
Jean-Claude, Mwanza, Désiré, Tshala-Katumbay, Thorkild, Tylleskär   +2 more
openaire   +2 more sources

Konzo risk factors, determinants and etiopathogenesis: what is new? A systematic review.

Neurotoxicology, 2021
Konzo is a toxico-nutritional upper motor neuron disease causing a spastic paraparesis in schoolchildren and childbearing women in some African countries. Almost a century since the first description of konzo, its underlying etiopathogenic mechanisms and
M. Baguma, F. Nzabara, G. Maheshe Balemba, E. B. Malembaka, Christiane Migabo, G. Mudumbi, V. Bito, J. Cliff, J. Rigo, J. Chabwine   +9 more
semanticscholar   +1 more source

Konzo in the Central African Republic

Neurology, 1994
We identified a new focus of konzo, an upper motor neuron disease, in a part of western Central African Republic. Interviews and high serum levels of thiocyanate indicate that cyanide exposure from insufficiently processed cassava may cause konzo. Abrupt onset, nonprogressive course, and seronegativity to HTLV-I clearly differentiate konzo from HTLV-I ...
T, Tylleskär, F D, Légué, S, Peterson, E, Kpizingui, P, Stecker   +4 more
openaire   +2 more sources

Long term follow-up of konzo patients

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997
Nine patients with konzo, a symmetric spastic paraparesis of acute onset that occurs during agricultural crises in cassava-growing areas, were re-examined after 14 years. Konzo outbreaks are associated with eating insufficiently processed bitter cassava and a low intake of essential amino acids. Bitter cassava contains cyanogenic glycosides; processing
J, Cliff, D, Nicala
openaire   +2 more sources

Konzo Disease: A household survey conducted in Mutondo community, Luampa district, Zambia

The Health Press Zambia
Introduction:Konzo is a neglected neurological disease characterized by sudden, non-progressive paralysis of the lower limbs, commonly linked to chronic consumption of cyanogenic cassava combined with protein deficiency.
Benaiah Silishebo Simatele, Davie Simwaba, D. Banda, D. Shempela, N. Sinyange   +4 more
semanticscholar   +1 more source

Konzo and Ebola in Bandundu region of Zaire

The Lancet, 1997
Vol 349 • March 1, 1997 621 confirmed that before the outbreaks of konzo in the dry season, shortcuts were taken in the soaking of cassava because of increased sales, especially in 1992. The outbreak in 1995 was also preceded by such shortcuts, prompted by a sudden build-up of traders in Popokabaka after a military road block had been set up east of ...
M, Banea, T, Tylleskär, H, Rosling
openaire   +2 more sources

Dietary Protein Supplementation Reverses Spinal Cord Neurodegeneration in a Rat Model of Bitter Cassava-Induced Konzo

Journal of medicine and health research
Background: Konzo, a neurological disorder linked to consumption of improperly processed Bitter Cassava, is characterized by motor neuron damage and paralysis, yet effective dietary interventions remain poorly understood.
Hebinuchi Amadi, L. K. David
semanticscholar   +1 more source

Effect of Konzo Risk on Fine Motor Skills in Nigerian School Children: A Case‒control Study of Dietary Cassava Exposure and Hand Dexterity Performance

Journal of disease and global health
Background: Konzo is a neglected neurological disease linked to chronic dietary exposure to cyanogenic cassava. Despite the emergence of interventions, research gaps persist regarding early motor deficits in children at risk.
L. David, Oboite Laura Osezele, Angela R. Wells   +2 more
semanticscholar   +1 more source

Sulphur-Rich Protein Supplementation Reverses Motor Impairment and Muscle Atrophy in a Rat Model of Konzo

Journal of international research in medical and pharmaceutical sciences
Background: Konzo is a neurological disorder caused by prolonged consumption of poorly processed bitter cassava, leading to upper motor neuron damage and spastic paralysis. Nutritional deficiency, particularly low sulphur amino acids, exacerbates cyanide
Hebinuchi Amadi, L. K. David, Precious Uahomo   +2 more
semanticscholar   +1 more source