Results 11 to 20 of about 32,838 (155)

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes. [PDF]

PLoS ONE, 2021
Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski   +4 more
doaj   +2 more sources

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice [PDF]

Stem Cell Research & Therapy, 2022
Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Zhuo Huang, Ruihuan Yang, Ruyi Li, Yining Zuo, Fan Gu, Miao He, Zhuan Bian   +6 more
doaj   +2 more sources

Hypoxia‐inducible factor‐1α attenuates renal podocyte injury in male rats in a simulated high‐altitude environment by upregulating Krüppel‐like factor 4 expression [PDF]

Experimental Physiology
Previous studies have shown that podocyte injury is involved in the development of proteinuria in rats under hypobaric hypoxia conditions. Prolyl hydroxylase inhibitors (PHIs) may reduce proteinuria.
Zeng Xiaoshan, Cheng Huan, Gan Zhilin, Mo Liwen, Zeng Yan, Cheng Yue   +5 more
doaj   +2 more sources

Transcription factor Krüppel‐like factor 4 upregulated G protein‐coupled receptor 30 alleviates intestinal inflammation and apoptosis, and protects intestinal integrity from intestinal ischemia–reperfusion injury [PDF]

Immunity, Inflammation and Disease, 2023
Introduction Intestinal ischemia/reperfusion (I/R) injury is a common clinical event occurring during multiple clinical pathological processes. Here, we designed this paper to discuss the role of G protein‐coupled receptor 30 (GPR30) playing in ...
Jie Yin, Xiaoli Xie, Jinfeng Yao, Xiaoxu Jin, Huiqing Jiang, Chenguang Ji   +5 more
doaj   +2 more sources

Author Correction: MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4 [PDF]

Scientific Reports, 2023
Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang   +8 more
doaj   +2 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]

, 2016
BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K, Hashimoto, Y, Ichikawa, T, Ichinose, M, Kikuchi, T, Koarai, A, Numakura, T, Okazaki, T, Onodera, K, Sato, K, Sugiura, H, Tamada, T, Tanaka, R, Yamada, M, Yanagisawa, S   +14 more
core   +4 more sources

KLF4 suppresses the proliferation and metastasis of NSCLC cells via inhibition of MSI2 and regulation of the JAK/STAT3 signaling pathway

Translational Oncology, 2022
Background: Non-small cell lung cancer (NSCLC) remains an aggresive tumor with poor survival rates. Krüppel-like factor 4 (KLF4) is known to be involved in progression of NSCLC; however, the detailed mechanism by which KLF4 regulates the progression of ...
Di-Di Luo, Feng Zhao
doaj   +1 more source

Overexpression of Krüppel-Like Factor 4 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Through c-Jun-NH2-Terminal Kinase/Epithelial-Mesenchymal Transition Signaling Pathway

Frontiers in Pharmacology, 2020
Krüppel-like factor 4 (KLF4) is a transcription factor and plays a vital role in cancer initiation and development. However, the role of Krüppel-like factor 4 in the metastasis of non-small cell lung cancer (NSCLC) is not clear.
Yanping Wu, Lianjun Lin, Xiang Wang, Yong Li, Zhonghui Liu, Wei Ye, Weiming Huang, Gang Lin, Haibo Liu, Jixin Zhang, Ting Li, Beilei Zhao, Liping Lv, Jian Li, Nanping Wang, Xinmin Liu   +15 more
doaj   +1 more source

Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]

PLoS ONE, 2012
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu, Xi Chen, Wen Zhang, Juan Li, Ren Xu, Timothy C Wang, Walden Ai, Chunming Liu   +7 more
doaj   +1 more source