Results 281 to 290 of about 260,030 (390)

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

Med Research, EarlyView.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin, Mingjun Lu, Jingwei Guo, Chenyang Wang, Teng Ma   +4 more
wiley   +1 more source

Pan-Immune-Inflammation Value (PIV) and Prognostic Nutritional Index (PNI) are Associated with Distant Metastasis in Colorectal Cancer with <i>KRAS</i> Mutation but Not in Those with <i>KRAS</i> Wild-Type. [PDF]

Int J Gen Med
Li Y, Zeng Y.
europepmc   +1 more source

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells [PDF]

, 2009
Cristina P. R. Xavier, Cristóvão F. Lima, Ana Preto, Raquel Seruca, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson   +5 more
openalex   +1 more source

Mutation profiling in differential diagnosis between TdT‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma

The Journal of Pathology, EarlyView.
Abstract Terminal deoxynucleotidyl transferase (TdT) is occasionally expressed in large B‐cell lymphoma (LBCL), and this causes difficulty in differential diagnosis from B‐lymphoblastic leukaemia/lymphoma (B‐ALL/LBL). We reviewed 31 cases of TdT‐positive LBCL and B‐ALL/LBL, and their final diagnosis included 19 diffuse large/high‐grade BCLs with MYC ...
Maria‐Myrsini Tzioni, Francesco Cucco, Lívia Rásó‐Barnett, Zi Chen, Andrew Wotherspoon, Katrin S Kurz, Ewelina Madej, Jasmine Makker, Anna E Strazda, Fang Guo, Caoimhe Egan, Elizabeth Soilleux, Liz Hook, Laszlo Krenacs, Julia T Geyer, Camille Laurent, Luc Xerri, Lenaïg Mescam, Lukas Plank, Lise Mette Rahbek Gjerdrum, Nicolas Lopez‐Hisijos, Timothy Greiner, Joseph Khoury, Wolfram Klapper, Ilske Oschlies, Andreas Rosenwald, German Ott, Ming‐Qing Du   +27 more
wiley   +1 more source

Recovery of Grip Strength Over Time After Complete Resection of KRAS-Positive Lung Cancer With Hypertrophic Pulmonary Osteoarthropathy: A Case Report. [PDF]

Thorac Cancer
Iguchi T, Kojima K, Hayashi D, Tokunaga T, Yoon H.   +4 more
europepmc   +1 more source

Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas

, 2008
Seung Woo Park, Jon M. Davison, Jerry M. Rhee, Ralph H. Hruban, Anirban Maitra, Steven D. Leach   +5 more
openalex   +1 more source

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia [PDF]

, 2009
Guanglu Shi, Liqin Zhu, Yan Sun, Ryan Bettencourt, Barbara Damsz, Ralph H. Hruban, Stephen F. Konieczny   +6 more
openalex   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

A small-sized imidazole-derived ligand binds to the KRAS promoter G-quadruplex and inhibits cancer growth with enhanced immunomodulation. [PDF]

J Biol Chem
Wang XD, Nie QW, Hu MH.
europepmc   +1 more source

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer.

Cold Spring Harbor Perspectives in Medicine, 2018
Andrew M. Waters, C. Der
semanticscholar   +1 more source