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KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma
Molecular Cancer TherapeuticsAbstract Pancreatic ductal adenocarcinoma (PDAC) is associated with significant morbidity and mortality and is projected to be the second leading cause of cancer-related deaths by 2030. Mutations in KRAS are found in the vast majority of PDAC cases and plays an important role in the development of the disease.
Minh T. Than +3 more
openaire +2 more sources
Targeting the MAPK Pathway in KRAS-Driven Tumors
Cancer Cell, 2020Matthias Drosten, Mariano Barbacid
exaly
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
Cell, 2018Chiara Ambrogio +2 more
exaly
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
Cell, 2018Lian-Sheng Li, Ulf Peters, Yuching Chen
exaly

