Results 1 to 10 of about 50,596 (166)

PIK3CA-mutations in breast cancer

Breast Cancer Research and Treatment, 2022
Abstract Purpose Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to determine the prevalence of PIK3CA-mutations in a cohort of early stage breast cancer patients and the association to the course of disease.
Martina Vetter, Volker Hanf, Carolin Hartung   +2 more
exaly   +5 more sources

A Neonate Diagnosed with Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome with Mutation [PDF]

Neonatal Medicine, 2023
Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP) is a rare genetic disorder characterized by megalencephaly, polymicrogyria, body overgrowth, and cutaneous capillary malformations. It has been reported recently that MCAP is related to
Young Mi Park, Yoon-Myung Kim, Seong Hee Oh, Hyun-Seung Jin   +3 more
doaj   +1 more source

Carcinogenesis of PIK3CA [PDF]

Hereditary Cancer in Clinical Practice, 2013
Abstract PIK3CA is the most frequently mutated oncogene in human cancers. PIK3CA is phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha. It controls cell growth, proliferation, motility, survival, differentiation and intracellular trafficking.
German, Sidra, Aslam, Hafiz Muhammad, Saleem, Shafaq, Raees, Aisha, Anum, Tooba, Alvi, Arsalan Ahmad, Haseeb, Abdul   +6 more
openaire   +3 more sources

Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example

Molecular Biomedicine
Compared with those in adenocarcinoma, PIK3CA mutations are more common in squamous cell carcinoma (SCC), which arises from stratified squamous epithelia that are usually exposed to adverse environmental factors. Although hotspot mutations in exons 9 and
Shutao Zheng, Yiyi Tan
exaly   +2 more sources

RAS–PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies [PDF]

Disease Models & Mechanisms
Lorenzo M. Fernandes, Jeffrey Tresemer, Angelica Vallejo, Alice Yao, Joshua P. Scallan, Michael T. Dellinger   +5 more
doaj   +2 more sources

Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer

Cancer Biology & Therapy, 2023
Significant improvement in targeted therapy for colorectal cancer (CRC) has occurred over the past few decades since the approval of the EGFR inhibitor cetuximab.
Yoon Sun Park, Joseph kim, Yea Seong Ryu, Jai-Hee moon, Yu Jin shin, Jeong Hee kim, Seung-Woo hong, Soo-A jung, Seul lee, Seung-Mi kim, Dae Hee lee, Do Yeon kim, Hyeseon yun, Ji-Eun you, Dong Il yoon, Chul Hee kim, Dong-In koh, Dong-Hoon jin   +17 more
doaj   +1 more source

A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

Molecular & Cellular Oncology, 2021
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized ...
Samuel J. Rodgers, Sabryn A. Hamila, Christina A. Mitchell, Lisa M. Ooms   +3 more
doaj   +1 more source

Utilizing Liquid Biopsy for Treatment Management in Bone-Dominant Metastatic Breast Cancer: A Case Report

Case Reports in Oncology, 2022
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women in the United States. In clinical practice, the standard method to confirm metastatic disease and tailor treatment is to biopsy a metastatic site.
Shirley Cheng, Edward Tri Nguyen, Jami Aya Fukui   +2 more
doaj   +1 more source

Clinical profile of overgrowth syndromes consistent with PROS (PIK3CA-related overgrowth syndromes)—A case series

Indian Dermatology Online Journal, 2020
Context: PIK3CA-related overgrowth syndrome (PROS) is characterized by focal and disproportionate growth of acral body structures in a mosaic pattern with varied phenotypes.
Lydia Mathew, Renu George, Sniya Sudhakar, Shyamkumar N Keshava, N A Fouzia   +4 more
doaj   +1 more source

PIK3CA as an oncogene in cervical cancer [PDF]

Oncogene, 2000
Amplification of chromosome arm 3q is the most consistent aberration in cervical cancer, and is implicated in the progression of dysplastic uterine cervical cells into invasive cancer. The present study employed the 'positional candidate gene' strategy to determine the contribution of PIK3CA, which is located in 3q26.3, in cervical tumorigenesis ...
Y Y, Ma, S J, Wei, Y C, Lin, J C, Lung, T C, Chang, J, Whang-Peng, J M, Liu, D M, Yang, W K, Yang, C Y, Shen   +9 more
openaire   +2 more sources