Results 41 to 50 of about 77,471 (339)

Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma

Cancer Biology & Medicine, 2020
Objective: In patients with head and neck squamous cell carcinoma (HNSCC), cetuximab [a monoclonal antibody targeting epidermal growth factor receptor (EGFR)] has been shown to improve overall survival when combined with radiotherapy in the locally ...
Olivia Leblanc, Sophie Vacher, Charlotte Lecerf, Emmanuelle Jeannot, Jerzy Klijanienko, Frédérique Berger, Caroline Hoffmann, Valentin Calugaru, Nathalie Badois, Anne Chilles, Maria Lesnik, Samar Krhili, Ivan Bieche, Christophe Le Tourneau, Maud Kamal   +14 more
doaj   +1 more source

Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCT

Efficacy and Mechanism Evaluation, 2022
Background: Complex trials with innovative designs are becoming increasingly common and offer the potential to improve patient outcomes in a shorter time frame.
Louise C Brown, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Susan D Richman, Philip Quirke, Rachel Butler, Helen Roberts, Janet Graham, Richard H Wilson, Timothy S Maughan   +12 more
doaj   +1 more source

Multiplexed Assays for Detection of Mutations in PIK3CA [PDF]

Clinical Chemistry, 2008
Abstract Background: Mutations in the PIK3CA gene (phosphoinositide-3-kinase, catalytic, alpha polypeptide) have recently been described in a number of cancers, and their detection is currently limited because of the low sensitivity of conventional sequencing techniques.
Board, Ruth E., Thelwell, Nicola J., Ravetto, Paul F., Little, Stephen, Ranson, Malcolm, Dive, Caroline, Hughes, Andrew, Whitcombe, David   +7 more
openaire   +2 more sources

Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma

Molecular Cancer, 2022
Although the prognostic outcomes of liver cancer (LC) cases have improved with the advancement in diagnostic technology and treatment methods, the transferability and recurrence of HCC and the 5-year and 10-year survival rates of patients have remained ...
Wei-Wei Liu, Lu Zheng, Rongguiyi Zhang, P. Hou, Jia-Kun Wang, Lin-Quan Wu, Jing Li   +6 more
semanticscholar   +1 more source

Contribution of 3q26-29 gene cluster to glioma invasion [PDF]

, 2015
Diffuse gliomas are the most common and lethal brain tumors. Cell invasion into the surrounding brain tissue is a hallmark feature of glioma. Understanding the mechanism of glioma invasion could lead to the discovery of novel therapeutic strategies to ...
Ramadoss, Archana
core   +1 more source

A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations

Orphanet Journal of Rare Diseases, 2021
Background PIK3CA -related disorders include vascular malformations and overgrowth of various tissues that are caused by postzygotic, somatic variants in the gene encoding phosphatidylinositol-3-kinase (PI3K) catalytic subunit alpha.
G. Canaud, Adrienne M. Hammill, Denise M. Adams, M. Vikkula, K. Keppler-Noreuil   +4 more
semanticscholar   +1 more source

RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells

World Journal of Gastroenterology, 2011
To explore the effects of siRNA silencing of PIK3CA on proliferation, migration and invasion of gastric cancer cells and to investigate the underlying mechanisms.The mutation of PIK3CA in exons 9 and 20 of gastric cancer cell lines HGC-27, SGC-7901, BGC-823, MGC-803 and MKN-45 was screened by polymerase chain reaction (PCR) followed by sequencing.
Xin-Ke, Zhou, Sheng-Song, Tang, Gao, Yi, Min, Hou, Jin-Hui, Chen, Bo, Yang, Ji-Fang, Liu, Zhi-Min, He   +7 more
openaire   +2 more sources

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single-Cell Level in CTCs From HR+/HER2- Metastatic Breast Cancer. [PDF]

Cancer Sci
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Rossi T, Palleschi M, Gianni C, Merloni F, Virga A, Bandini S, Angeli D, Tebaldi M, Maltoni R, Ulivi P, Musolino A.   +10 more
europepmc   +2 more sources

PIK3CA mutation status, progression and survival in advanced HR + /HER2- breast cancer: a meta-analysis of published clinical trials

BMC Cancer, 2022
Background Approximately 40% of hormone receptor positive/human epidermal receptor 2 negative (HR + /HER2-) metastatic breast cancer (mBC) patients harbor phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA ) mutations ...
M. Fillbrunn, J. Signorovitch, F. André, I. Wang, I. Lorenzo, A. Ridolfi, Jinhee Park, Akanksha Dua, H. Rugo   +8 more
semanticscholar   +1 more source

PIK3CA mutation.

, 2022
PIK3CA mutation.
Vania Myralda Giamour Marbun (12884117), Toar Jean Maurice Lalisang (12884120), Linda Erlina (9914846)   +2 more
core   +1 more source