Results 61 to 70 of about 77,471 (339)

PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibfibroipose vascular anomaly (FAVA)

Diagnostic Pathology, 2022
Background Fibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene were identified at a frequency of 62.5% in ...
Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa, Eiichi Morii   +12 more
doaj   +1 more source

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.

Brain : a journal of neurology, 2021
Cavernous malformations (CMs) affecting the central nervous system occur in approximately 0.16% to 0.4% of the general population. The majority (85%) of the CMs are in a sporadic form, but the genetic background of sporadic CMs remains enigmatic.
T. Hong, Xiao Xiao, Jian Ren, Bing Cui, Yuru Zong, Jiandong Zou, Zqi Kou, Nan Jiang, Guo-Lu Meng, G. Zeng, Y. Shan, Hao Wu, Zan Chen, Jian-Tao Liang, Xinru Xiao, Jie Tang, Yu-Kui Wei, M. Ye, Li-Yong Sun, Gui-Lin Li, P. Hu, R. Hui, Hongqi Zhang, Yibo Wang   +23 more
semanticscholar   +1 more source

Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment. [PDF]

PLoS ONE, 2008
PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target.
Nuo Yang, Jia Huang, Joel Greshock, Shun Liang, Andrea Barchetti, Kosei Hasegawa, Sarah Kim, Antonis Giannakakis, Chunsheng Li, Anne O'Brien-Jenkins, Dionyssios Katsaros, Ralf Bützow, George Coukos, Lin Zhang   +13 more
doaj   +1 more source

PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

JCO Precision Oncology, 2022
The phosphatidylinositol 3-kinase (PI3K) pathway is an intracellular pathway activated in response to progrowth signaling, such as human epidermal growth factor receptor 2 (HER2) and other kinases.
Aryana R. Rasti, A. Guimarães-Young, F. Datko, V. Borges, D. Aisner, E. Shagisultanova   +5 more
semanticscholar   +1 more source

Pharmacodynamic approach to assessing leukopenia as a marker of treatment efficacy in CDK4/6 inhibitor therapy in patients with HR+/HER2- metastatic breast cancer: a multicenter real-world study

Реальная клиническая практика: данные и доказательства
Relevance. The introduction of CDK4/6 inhibitors (palbociclib, ribociclib, and abemaciclib) into clinical practice has significantly improved the treatment outcomes of patients with metastatic HR+/HER2-breast cancer.
A. V. Fateeva, E. V. Eliseeva, A. V. Vdovenko, V. A. Komissarova, R. A. Zukov, D. M. Ponomarenko, E. I. Rossokha, L. M. Ryabova   +7 more
doaj   +1 more source

Oncogenic activation of PIK3CA in cancers: Emerging targeted therapies in precision oncology

Genes and Diseases
Phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of a p110 catalytic subunit and a p85 regulatory subunit. The PIK3CA gene, which encodes the p110α, is the most frequently mutated oncogene in cancer.
Yuxiang Wang, V. Rozen, Yiqing Zhao, Zhenghe Wang   +3 more
semanticscholar   +1 more source

Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations

New England Journal of Medicine, 2021
BACKGROUND Cerebral cavernous malformations (CCMs) are common sporadic and inherited vascular malformations of the central nervous system. Although familial CCMs are linked to loss-of-function mutations in KRIT1 (CCM1), CCM2, or PDCD10 (CCM3), the ...
M. Peyre, D. Miyagishima, F. Bielle, F. Chapon, M. Sierant, Quitterie Venot, J. Lerond, P. Marijon, Samiya Abi-Jaoude, Tuan Le Van, K. Labreche, R. Houlston, M. Faisant, S. Clemenceau, A. Boch, A. Nouet, A. Carpentier, J. Boetto, A. Louvi, M. Kalamarides   +19 more
semanticscholar   +1 more source

Case Report of Tumour Response to Capivasertib after Exposure to Alpelisib in PIK3CA-mutated metastatic breast cancer

Journal of Clinical Question
Sequential targeting of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer remains poorly described. We report a case of a 67-year-old woman
Han Yi Lee, Joshua Zhi Chien Tan, Raymond Chee Hui Ng   +2 more
doaj   +1 more source

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase [PDF]

, 2017
Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials.
Glenn S. Cowley, Root, David E., William C. Hahn, Kory, Nora, Kıvanç Birsoy, Widlund, Hans R., Aviad Tsherniak, Barbara A. Weir, Singh, Shambhavi, David E. Root, Vazquez, Francisca, Asara, John M., Elizaveta Freinkman, Susan E. Moody, Francisca Vazquez, Birsoy, Kıvanç, John M. Asara, Cowley, Glenn S., Spardy, Nicole A., Nina Ilic, Nicole A. Spardy, Aguirre, Andrew J., Sabatini, David, David M. Sabatini, DeAngelo, Joseph D., Joseph D. DeAngelo, Moody, Susan E., Weir, Barbara A., Pacold, Michael Edward, Andrew J. Aguirre, Hans R. Widlund, Shambhavi Singh, Ilic, Nina, Michael E. Pacold, Hahn, William C., Nora Kory, Tsherniak, Aviad, Freinkman, Elizaveta   +37 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source