Results 71 to 80 of about 77,471 (339)
Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian Cancer
Cancer Management and Research, 2021 Tao Guo,1 Xue Dong,2 Shanli Xie,3 Ling Zhang,4 Peibin Zeng,5 Lin Zhang6 1Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 2Department of Gynecology, Cheng
Guo T +5 more
doaj
, 2022 Key message The Norwegian Institute of Public Health was commissioned to evaluate molecular tests for the identification of somatic PIK3CA mutations in men and postmenopausal women with HR+/HER2–, advanced or metastatic breast cancer (BC).
Hamidi Ashtiani, Vida +3 more
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Pharmacological ResearchEpithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have significantly enhanced the treatment outcomes in non-small cell lung cancer (NSCLC) patients harboring EGFR mutations.
Xiaohong Liu +3 more
semanticscholar +1 more source
Alpelisib for the treatment of PIK3CA-related head and neck lymphatic malformations and overgrowth
Genetics in Medicine, 2022 Purpose: PIK3CA-related overgrowth spectrum (PROS) conditions of the head and neck are treatment challenges. Traditionally, these conditions require multiple invasive interventions, with incomplete malformation removal, disfigurement, and possible ...
T. Wenger +18 more
semanticscholar +1 more source
Journal of Clinical OncologyClinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available.
J. Nowak +21 more
semanticscholar +1 more source
Molecular Cancer, 2022 Background PIK3CA mutation and PTEN suppression lead to tumorigenesis and drug resistance in colorectal cancer (CRC). There is no research on the role of circular RNAs (circRNAs) in regulating PIK3CA mutation and MEK inhibitor resistance in CRC.
Xiao-Dan Chong +14 more
semanticscholar +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Alpelisib for PIK3CA-mutated advanced gynecological cancers: First clues of clinical activity.
Gynecologic OncologyOBJECTIVE Recurrent gynecological tumors (e.g., endometrial, and ovarian cancers) are incurable diseases; therefore, new treatment options are urgently needed.
A. Passarelli +23 more
semanticscholar +1 more source
Therapeutics and Clinical Risk Management, 2021 The PI3K/AKT/mTOR pathway has long been known to play a major role in the growth and survival of cancer cells. Breast tumors often harbor PIK3CA gene alterations, which therefore constitute a rational drug target.
D. Chang, Wei-Li Ma, Yen-Shen Lu
semanticscholar +1 more source