Results 91 to 100 of about 77,471 (339)

CRISPR-Based Single-Nucleotide Editing of PIK3CA c.3140A>G (p.His1047Arg) in MCF7 Breast Cancer Cells Enhances Proliferative Potential [PDF]

Cell Journal
Objective: The PI3K/Akt signaling pathway plays a central role in regulating cell growth, survival, and metabolism,and its dysregulation is a hallmark of many cancers.
Omid Dehqani Dashtabi, Azin Amoozeidi, Saman Hosseinkhani, Seyed Javad Mowla   +3 more
doaj   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival

Cancers, 2022
Simple Summary Mutations of the PIK3CA gene are thought to contribute to the development of head and neck squamous cell carcinomas (HNSCC), especially those associated with human papillomavirus infection.
Daniela Cochicho, S. Esteves, M. Rito, Fernanda Silva, Luís Martins, P. Montalvão, Mário Cunha, M. Magalhães, R. M. Gil da Costa, Ana Félix   +9 more
semanticscholar   +1 more source

Pathological Characteristics of Mutations in PIK3CA and TP53 Genes in Breast Cancer Cases from Qinghai Area

Zhongliu Fangzhi Yanjiu
ObjectiveTo analyze ethnic differences in mutations of the PIK3CA and TP53 genes among breast cancer patients from the Han, Tibetan, and Hui ethnic groups in Qinghai, China, and their associations with clinicopathological characteristics.
Xueyue LI, Jing HU, Hongyuan LIAO, Haiqin ZHANG, Xiude LI, Hao LEI, Xiaofeng ZHOU   +6 more
doaj   +1 more source

PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup.

PLoS ONE, 2014
PurposePIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase (PI3K) is mutated and/or amplified in various neoplasia, including lung cancer.
Lei Wang, Haichuan Hu, Yunjian Pan, Rui Wang, Yuan Li, Lei Shen, Yongfu Yu, Hang Li, Deng Cai, Yihua Sun, Haiquan Chen   +10 more
doaj   +1 more source

PIK3CA Is Regulated by CUX1, Promotes Cell Growth and Metastasis in Bladder Cancer via Activating Epithelial-Mesenchymal Transition

Frontiers in Oncology, 2020
PIK3CA is a key component of phosphatidylinositol 3-kinase (PI3K) pathway that its involvement in tumorigenesis has been revealed by previous research.
Zhongyu Wang, Jun Shang, Zhiqin Li, Huanhuan Li, Chufan Zhang, Kai He, Shikang Li, Wen Ju   +7 more
doaj   +1 more source

A Pilot Study to Non-Invasively Track PIK3CA Mutation in Head and Neck Cancer

, 2018
Background: PIK3CA pathways are the most frequently mutated oncogenic pathway in head and neck squamous cell carcinoma (HNSCC), including virally driven HNCs. PIK3CA is involved in the PI3K-PTEN-mTOR signalling pathway.
Chamindie Punyadeera, Kenny, Liz, Punyadeera, Chamindie, Schmidt, Henri, Mokany, Elisa, Richard J.N. Allcock, Lit Yeen Tan, Liz Kenny, Henri Schmidt, Allcock, Richard JN, Elisa Mokany, Tan, Lit Yeen, Kulasinghe, Arutha, Lit Yeen Tan, Richard J.N. Allcock, Arutha Kulasinghe   +15 more
core   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

Genotypes and phenotypes heterogeneity in PIK3CA-related overgrowth spectrum and overlapping conditions: 150 novel patients and systematic review of 1007 patients with PIK3CA pathogenetic variants

Journal of Medical Genetics, 2022
Background Postzygotic activating PIK3CA variants cause several phenotypes within the PIK3CA-related overgrowth spectrum (PROS). Variant strength, mosaicism level, specific tissue involvement and overlapping disorders are responsible for disease ...
A. Mussa, C. Leoni, M. Iacoviello, D. Carli, C. Ranieri, A. Pantaleo, P. Buonuomo, R. Bagnulo, G. Ferrero, A. Bartuli, D. Melis, S. Maitz, D. Loconte, Antonella Turchiano, M. Piglionica, A. De Luisi, F. Susca, N. Bukvic, C. Forleo, A. Selicorni, G. Zampino, R. Onesimo, G. Cappuccio, L. Garavelli, C. Novelli, L. Memo, Carla Morando, M. Della Monica, M. Accadia, Martina Capurso, C. Piscopo, A. Cereda, M. D. Di Giacomo, V. Saletti, A. Spinelli, P. Lastella, R. Tenconi, V. Dvořáková, A. Irvine, N. Resta   +39 more
semanticscholar   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source