Results 111 to 120 of about 77,471 (339)

Alpelisib in the Treatment of Breast Cancer: A Short Review on the Emerging Clinical Data

Breast Cancer: Targets and Therapy, 2020
Avan J Armaghani, Hyo Sook Han Department of Breast Oncology, Moffitt McKinley Outpatient Center, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USACorrespondence: Avan J Armaghani Email avan.armaghani@moffitt.orgAbstract: Hormone ...
Armaghani AJ, Han HS
doaj  

Mutations in Diffuse Gliomas: An Update on Molecular Stratification, Prognosis, Recurrence, and Aggressiveness

Clinical Medicine Insights: Oncology, 2022
Introduction: PIK3CA is one of the most mutated oncogenes in solid tumors. In breast cancer (ER-positive, HER2-negative), these events represent a predictive biomarker of response to alpelisib.
Cheila Brito, Ana Tomás, Ana Azevedo, Susana Esteves, Manuela Mafra, Lúcia Roque, Marta Pojo   +6 more
doaj   +1 more source

Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer

The enzyme phosphatidylinositide-3-kinase (PI3K) regulates cellular proliferation and apoptosis. Somatic mutations in the PIK3CA gene can accelerate these processes and significantly contribute to the development and progression of breast cancer.
Ismail Saygin, Sevdegul Aydin Mungan, Zeynep Sagnak Yilmaz, Zeynep Turkmen Usta, Gizem Teoman   +4 more
core   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling [PDF]

, 2017
Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown.
Moniz, Larissa S., Parker, VER, Bart Vanhaesebroeck (34252), Laurent Sansregret (9464039), Birkbak, NJ, Swanton, C, Castillo, SD, Sansregret, L, Graupera, M, Mariona Graupera (763919), Sally M. Dewhurst, Wayne A Phillips (11283540), Mariona Graupera, McGranahan, Nicholas, Berenjeno, IM, Piñeiro, Roberto, Semple, RK, Nicholas McGranahan (594459), Charles Swanton, Swanton, Charles, Graupera i Garcia-Milà, Mariona, Morelli, D, Phillips, Wayne A., Scudamore, Cheryl L., Berenjeno, Inma M., Meniel, Valerie, Charles Swanton (236153), Pearce, Wayne, Kanu, Nnennaya, Cheryl L. Scudamore, Kanu, N, Robert K. Semple, Robert K Semple (9104531), Alan Clarke, Daniele Morelli, Cheryl L Scudamore (8268216), Vanhaesebroeck, B, Nnennaya Kanu, Evelyn Lau (11283528), Birkbak, Nicolai J., Morelli, Daniele, Victoria ER Parker (11283531), Karen G. Montgomery, Valerie Meniel (11283525), McGranahan, N, Karen G Montgomery (11283534), Phillips, Wayne A, Daniele Morelli (9104501), Semple, Robert K; id_orcid, Srinivas, S, Wayne Pearce, Nicolai J. Birkbak, Victoria E. R. Parker, Moniz, LS, Larissa S. Moniz, Nicholas McGranahan, Srinivas, Shankar, Semple, Robert K., Meniel, V, Inma M. Berenjeno, Piñeiro, R, Castillo, Sandra D, Vanhaesebroeck, Bart, Wayne Pearce (34243), Berenjeno, Inma M, Moniz, Larissa S, Wayne A. Phillips, Lau, Evelyn, Montgomery, Karen G, Roberto Piñeiro (104782), Dewhurst, Sally M, Parker, Victoria E. R., Montgomery, KG, Clarke, Alan, Inma M Berenjeno (11283516), Parker, Victoria E R, Nnennaya Kanu (3426848), Dewhurst, SM, Larissa S Moniz (11283537), Sandra D Castillo (11283519), Sansregret, Laurent, Scudamore, CL, Clarke, A, Scudamore, Cheryl L, Sandra D. Castillo, Evelyn Lau, Shankar Srinivas, Castillo, Sandra D., Dewhurst, Sally M., Bart Vanhaesebroeck, Pearce, W, Laurent Sansregret, Phillips, WA, Lau, E, Graupera, Mariona, Montgomery, Karen G., Shankar Srinivas (185119), Sally M Dewhurst (11283522), Nicolai J Birkbak (8990522), Valerie Meniel, Roberto Piñeiro, Alan Clarke (3409220), Birkbak, Nicolai J   +102 more
core   +2 more sources

Correlation between PIK3CA mutation and clinicopathological features and prognosis of breast cancer [PDF]

Jichu yixue yu linchuang
Objective To find the correlation between phosphatidylinositol kinase-3 catalytic subunit A gene (PIK3CA) mutation and pathological features as well as clinical prognosis of breast cancer.
Yiheliman·MAIMAITI, CAO Yanzhen, WANG Cuicui, YUE Na, LIANG Liping
doaj   +1 more source

PIK3CA expression in ESCC.

, 2014
Representative immunohistochemistry images of PIK3CA expression across multiple tumor grades. PIK3CA protein was localized on the cytoplasm of tumor cells. Tumors were scored on a scale from grade 0 to 3+.
Jianming Ying (155982), Shaokai Zhang (603032), Yanling Yuan (603033), Yongqiang Xie (603034), Liyan Xue (149161), Ling Shan (155985), Lin Wang (11986), Ning Lu (22589)   +7 more
core   +1 more source

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes [PDF]

, 2012
PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics.
Stacy L. Moulder, Ignacio Garrido-Laguna, Sarina A. Piha-Paul, Wheler, Jennifer J, David S. Hong, Hong, David S, Piha-Paul, Sarina A, Kurzrock, Razelle, Gerald S. Falchook, Apostolia M. Tsimberidou, J. Jack Lee, Janku, Filip, Jennifer J. Wheler, Razelle Kurzrock, Naing, Aung, Fu, Siqing, Rajyalakshmi Luthra, Luthra, Rajyalakshmi, Moulder, Stacy L, Filip Janku, Vanda M. T. Stepanek, Tsimberidou, Apostolia M, Falchook, Gerald S, Lee, J Jack, Stepanek, Vanda M, Garrido-Laguna, Ignacio, Siqing Fu, Aung Naing   +27 more
core   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Clinical-Pathologic Analysis of Breast Cancer With PIK3CA Mutations in Chinese Women

Technology in Cancer Research & Treatment, 2020
Purpose: Mutations of PIK3CA have recently been shown to play an important role in the pathogenesis and progression of breast neoplasms. The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated.
Jing Lian MS, En-Wei Xu PhD, Yan-Feng Xi PhD, Hui-Wen Wang MS, Peng Bu MS, Jin-fen Wang BS, Li-Xia Wang BS   +6 more
doaj   +1 more source