Results 121 to 130 of about 77,471 (339)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Identification of activating somatic mutations in the PIK3CA gene in breast tumors and determination of their minimal set for clinical diagnostic testing

Alʹmanah Kliničeskoj Mediciny
Background: For effective screening of breast cancer patients for candidates for target therapy with alpelisib, it is necessary to identify activating somatic mutations in the PIK3CA gene by allele specific polymerase chain reaction (PCR); this requires ...
Ulyana A. Boyarskih, Andrey A. Kechin, Alyona V. Zyuzyukina, Yevgeny A. Khrapov, Igor P. Oscorbin, Yefim Y. Alexeenok, Galina A. Avdiyuk, Ruslan A. Zukov, Nikolay E. Kushlinskii, Maksim L. Filipenko   +9 more
doaj   +1 more source

Mutations in PIK3CA and GTF2i.

, 2019
PIK3CA and GTF2i have been amplified from total RNA extracted from thymoma, sequenced and compared to reference sequences. A. C/A mutation in exon 2 of PIK3CA in B2/ B3 thymoma #3149. B.
Claire Merveilleux du Vignaux (6495215), Jean-Michel Maury (6495212), Gabrielle Drevet (6495218), Lara Chalabreysse (6495224), François Tronc (6495227), Virginie Zarza (6495221), Carine Maisse (282870), Nicolas Girard (321735), Christine Dolmazon (314624), Barbara Gineys (4593301), Caroline Leroux (314628)   +10 more
core   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients

, 2015
Min Liang,1,* Boyun Shi,1,* Jifang Liu,1 Lu He,2 Gao Yi,1 Lin Zhou,1 Guifang Yu,1 Xinke Zhou1,* 1Department of Oncology, The fifth affiliated hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of
Zhou L, Liu J, Shi B, Yu G, Liang M, He L, Yi G, Zhou X   +7 more
core  

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data

Journal of Ovarian Research, 2019
Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancer in female worldwide. PIK3CA has been proven to be a strong prognostic biomarker in UCEC.
Yinglian Pan, Li Ping Jia, Yuzhu Liu, Yixu Han, Qingchun Deng   +4 more
doaj   +1 more source

The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China

, 2019
Haibo Wu,1,* Wei Wang,2,3,* Jun Du,1,* Hong Li,2,3 Huogang Wang,2,3 Liangliang Huang,1 Hang Xiang,2,3 Jing Xie,1 Xiaoli Liu,2,3 Heng Li,1 Wenchu Lin2,3 1Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and ...
Liu X, Li H, Xie J, Lin W, Wang W, Xiang H, Du J, Wang H, Huang L, Wu H   +9 more
core  

Prävalenz von PIK3CA-Genmutationen beim Mammakarzinom [PDF]

, 2018
Der PI3K-AKT Signalweg ist einer der am häufigsten fehlregulierten Signalwege bei Krebs. Ca. 30% der Brustkrebstumoren weisen eine genetische Veränderung im PIK3CA Gen auf. Hotspot Mutationen werden in Exon 9 und Exon 20 beschrieben.
Reinhardt, Kristin
core   +1 more source