Results 101 to 110 of about 77,471 (339)

PVT1 Mediates Cell Proliferation, Apoptosis and Radioresistance in Nasopharyngeal Carcinoma Through Regulating miR-515-5p/PIK3CA Axis

Cancer Management and Research, 2020
Yanyan Han,1 Fang Li,2 Jun Xie,2 Yi Wang,2 Hua Zhang1 1Department of Otolaryngology, The First Affiliate Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2Department of Otolaryngology, Urumqi Eye and ENT ...
Han Y, Li F, Xie J, Wang Y, Zhang H
doaj  

Functional role of SGK3 in PI3K/Pten driven liver tumor development

BMC Cancer, 2019
Background Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression.
Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi, Xin Chen   +11 more
doaj   +1 more source

Immunostaining analysis of PIK3CA in OC.

, 2013
A. Left: S-OC negative for PIK3CA expression; right: S-OC positive for PIK3CA expression. B. Left: E-OC negative for PIK3CA expression; right: E-OC positive for PIK3CA expression. Magnification 40X. Magnification of the insets 10X.
Nicola Rinaldo (280461), Fulvio Zullo (280463), Renato Franco (184143), Paola Bruni (220060), Marianna Scrima (184137), Valter Agosti (280467), Giuseppe Viglietto (184159), Federica Zito Marino (280465), Alfina Quintiero (280466), Simona Losito (280464), Carmela De Marco (184139), Carmine Malzoni (280462), Fernanda Fabiani (184141)   +12 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Targeted therapy in patients with PIK3CA-related overgrowth syndrome

Nature, 2018
CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the ...
Quitterie Venot, T. Blanc, S. H. Rabia, L. Berteloot, Sophia Ladraa, J. Duong, E. Blanc, Simon C. Johnson, Clément Hoguin, O. Boccara, S. Sarnacki, N. Boddaert, S. Pannier, F. Martínez, S. Magassa, Junna Yamaguchi, B. Knebelmann, P. Merville, N. Grenier, D. Joly, V. Cormier-Daire, C. Michot, C. Bôle-Feysot, A. Picard, V. Soupre, S. Lyonnet, J. Sadoine, L. Slimani, C. Chaussain, C. Laroche-Raynaud, L. Guibaud, C. Broissand, J. Amiel, C. Legendre, F. Terzi, G. Canaud   +35 more
semanticscholar   +1 more source

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

Nature, 2020
Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment1,2.
Kwanha Yu, Chia-Ching John Lin, Asante Hatcher, B. Lozzi, Kathleen Kong, Emmet Huang-Hobbs, Yi-Ting Cheng, V. Beechar, Wenyi Zhu, Yiqun Zhang, Fengju Chen, G. Mills, C. Mohila, C. Creighton, J. Noebels, Kenneth L. Scott, B. Deneen   +16 more
semanticscholar   +1 more source

Results of PIK3CA mutations.

, 2014
Results of PIK3CA mutations.
Angela Ragazzini (538699), Emanuela Scarpi (382324), Wainer Zoli (11120), Dino Amadori (11130), Stefano Tamberi (538697), Giovanni Luca Frassineti (16187), Laura Capelli (509585), Eva Freier (538696), Paola Ulivi (11121), Andrea Casadei Gardini (509580), Massimo Giannini (538695), Alassandro Passardi (538698)   +11 more
core   +1 more source

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report [PDF]

, 2013
Introduction: In this report, we present the case of a patient affected by appendiceal cystadenoma, a colorectal adenocarcinoma, and a concomitant bladder carcinoma, as well as the results of the molecular study of the most relevant mutational pathways ...
Cossu, Antonio, Paliogiannis, Panagiotis, Pulighe, Fabio, Trignano, Mario, Scognamillo, Fabrizio, Colombino, Maria, Palmieri, Giuseppe   +6 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source