Results 81 to 90 of about 77,471 (339)

Enhancing postmenopausal osteoporosis: a study of KLF2 transcription factor secretion and PI3K-Akt signaling pathway activation by PIK3CA in bone marrow mesenchymal stem cells

Archives of Medical Science
Introduction Mesenchymal stem cells can develop into osteoblasts, making them a promising cell-based osteoporosis treatment. Despite their therapeutic potential, their molecular processes are little known.
Wenjie Ma, Chen Li
doaj   +1 more source

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma [PDF]

, 2017
BACKGROUND: We investigated the epidemiologic characteristics and prognostic significance of PIK3CA mutations/amplifications in curative resected liposarcoma.
김경식, 최영득, 허혁, 박규현, 이영한, 김주훈, 신규호, 김성훈, 김효송, 라선영, 안중배, 서진석, 노성훈   +12 more
core   +1 more source

Survival Outcomes in Older Adults with Axial Spondyloarthritis and Concomitant Cancer

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I. Ruiz, Sharon H. Giordano, Alexis R. Ogdie, Maria E. Suarez‐Almazor   +7 more
wiley   +1 more source

PIK3CA mutations in endocrine-resistant breast cancer

Scientific Reports
Around 75% of breast cancer (BC) patients have tumors expressing the predictive biomarker estrogen receptor α (ER) and are offered endocrine therapy. One-third eventually develop endocrine resistance, a majority with retained ER expression.
C. Schagerholm, S. Robertson, H. Toosi, E. Sifakis, Johan Hartman   +4 more
semanticscholar   +1 more source

Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited

Cellular and Molecular Life Sciences, 2022
PIK3CA mutations are amongst the most prevalent somatic mutations in cancer and are associated with resistance to first-line treatment along with low survival rates in a variety of malignancies.
Daniel N. Hall, R. Benndorf
semanticscholar   +1 more source

The extract of Polygonum capitatum alleviates hyperoxaluria-induced oxidative stress by targeting the PI3K-ERK-NRF2 signaling pathway

Food Science and Human Wellness
Polygonum capitatum (Buch.-Ham. ex D. Don) H. Gross is a perennial herb belonging to the Polygonaceae family, mainly distributed in Southwestern China. P.
Kai Li, Songsong Tan, Hao Su, Lin Wei, Weiming Chen, Dongbo Yuan, Bo Yan, Fa Sun, Can Li, Kehua Jiang, Jianguo Zhu   +10 more
doaj   +1 more source

PIK3CA mutations in Peruvian patients with HER2-amplified and triple negative non-metastatic breast cancers

Hematology/Oncology and Stem Cell Therapy, 2014
PURPOSE: To determine the frequency of PIK3CA mutations in a Peruvian cohort with HER2-amplified and triple negative breast cancers (TNBC). METHODS: We analyzed two cohorts of 134 primary non-metastatic breast cancer patients from Peru. Cohorts consisted
Carlos A Castaneda, Marco Lopez-Ilasaca, Joseph A Pinto, Michelle Chirinos-Arias, Franco Doimi, Silvia P Neciosup, Katerin I Rojas, Tatiana Vidaurre, Justin M Balko, Carlos L Arteaga, Henry L Gomez   +10 more
doaj   +1 more source

Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays

Advanced Functional Materials, EarlyView.
Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao, Ilayda Namli, Joseph Christakiran Moses, Youdi Liu, Suihong Liu, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Ibrahim T. Ozbolat   +7 more
wiley   +1 more source

PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway

Annals of Translational Medicine, 2021
Background Triple-negative breast cancer (TNBC) is a malignant subtype of breast cancer, the main treatments for which are chemotherapy and surgery. PIK3CA is an oncogene that encodes the p110α subunit of class IA PI3K to regulate cell proliferation and ...
Huayu Hu, Jun-Yong Zhu, Y-S Zhong, Rui-Li Geng, Yashuang Ji, Qingyu Guan, Chen-Yan Hong, Yufan Wei, Ningning Min, Ai-Ying Qi, Yanjun Zhang, Xi-ru Li   +11 more
semanticscholar   +1 more source

Genotype-directed Targeted Therapy for Pediatric Vascular Malformations: A Systematic Review

Journal of Indian Association of Pediatric Surgeons
Background: Pediatric vascular malformations are rare, heterogeneous disorders increasingly driven by somatic mutations affecting key molecular pathways, particularly the PI3K–AKT–mTOR and RAS–MAPK signaling cascades.
Bitesh Kumar, Nidhi Patil, Prabudh Goel, Vishesh Jain, Devendra Kumar Yadav, Anjan Kumar Dhua, Divya Jain, Shubhendu Singh   +7 more
doaj   +1 more source