Results 1 to 10 of about 486 (117)

Canonical or noncanonical? Structural plasticity of serine protease-binding loops in Kunitz-STI protease inhibitors. [PDF]

Protein Sci, 2023
AbstractThe Kunitz‐Soybean Trypsin Inhibitor (Kunitz‐STI) family is a large family of proteins with most of its members being protease inhibitors. The versatility of the inhibitory profile and the structural plasticity of these proteins, make this family a promising scaffold for designing new multifunctional proteins.
Guerra Y, Armijos-Jaramillo V, Pons T, Tejera E, Berry C.   +4 more
europepmc   +6 more sources

Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop? [PDF]

Journal of Structural Biology, 2016
Bi-functional inhibitors from the Kunitz-type soybean trypsin inhibitor (STI) family are glycosylated proteins able to inhibit serine and aspartic proteases. Here we report six crystal structures of the wild-type and a non-glycosylated mutant of the bifunctional inhibitor E3Ad obtained at different pH values and space groups.
Yasel Guerra, Pedro A. Valiente, Tirso Pons, Colin Berry, E. Rudiño-Piñera   +4 more
core   +8 more sources

Poplar protease inhibitor expression differs in an herbivore specific manner. [PDF]

BMC Plant Biol, 2021
Eberl F, Fabisch T, Luck K, Köllner TG, Vogel H, Gershenzon J, Unsicker SB.   +6 more
europepmc   +3 more sources

Virtual screening and molecular dynamics simulation study of plant protease inhibitors against SARS-CoV-2 envelope protein. [PDF]

Inform Med Unlocked, 2022
Kirar M, Singh H, Sehrawat N.
europepmc   +1 more source

Insulin-Loaded Soybean Trypsin Inhibitor-Chitosan Nanoparticles: Preparation, Characterization, and Protective Effect Evaluation. [PDF]

Polymers (Basel), 2023
Zhang Y, Liu R, Feng Q, Li H, Li Y, Liu X.   +5 more
europepmc   +1 more source

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity-A Review. [PDF]

Molecules, 2023
Kolodziejczyk-Czepas J, Czepas J.
europepmc   +1 more source

Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets. [PDF]

Int J Mol Sci, 2022
Bonturi CR, Silva Teixeira AB, Rocha VM, Valente PF, Oliveira JR, Filho CMB, Fátima Correia Batista I, Oliva MLV.   +7 more
europepmc   +1 more source

Interactions between Soybean Trypsin Inhibitor and Chitosan in an Aqueous Solution. [PDF]

Polymers (Basel), 2023
Zhang Y, Liu R, Li H, Li Y, Liu X.
europepmc   +1 more source

Peptides Derived from a Plant Protease Inhibitor of the Coagulation Contact System Decrease Arterial Thrombus Formation in a Murine Model, without Impairing Hemostatic Parameters. [PDF]

J Clin Med, 2023
De Souza DA, Salu BR, Nogueira RS, de Carvalho Neto JCS, Maffei FHA, Oliva MLV.   +5 more
europepmc   +1 more source

Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species. [PDF]

Cell Death Discov, 2023
Schiavi A, Cirotti C, Gerber LS, Di Lauro G, Maglioni S, Shibao PYT, Montresor S, Kirstein J, Petzsch P, Köhrer K, Schins RPF, Wahle T, Barilà D, Ventura N.   +13 more
europepmc   +1 more source