Results 1 to 10 of about 490 (118)

Canonical or noncanonical? Structural plasticity of serine protease-binding loops in Kunitz-STI protease inhibitors. [PDF]

Protein Sci, 2023
AbstractThe Kunitz‐Soybean Trypsin Inhibitor (Kunitz‐STI) family is a large family of proteins with most of its members being protease inhibitors. The versatility of the inhibitory profile and the structural plasticity of these proteins, make this family a promising scaffold for designing new multifunctional proteins.
Guerra Y, Armijos-Jaramillo V, Pons T, Tejera E, Berry C.   +4 more
europepmc   +6 more sources

Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop? [PDF]

Journal of Structural Biology, 2016
Bi-functional inhibitors from the Kunitz-type soybean trypsin inhibitor (STI) family are glycosylated proteins able to inhibit serine and aspartic proteases. Here we report six crystal structures of the wild-type and a non-glycosylated mutant of the bifunctional inhibitor E3Ad obtained at different pH values and space groups.
Guerra, Yasel, Valiente, Pedro A., Pons, Tirso, Berry, Colin, Rudiño-Piñera, Enrique   +4 more
core   +8 more sources

Antitumor and HIV‐1 Reverse Transcriptase Inhibitory Activities of a Hemagglutinin and a Protease Inhibitor from Mini‐Black Soybean [PDF]

Evidence-Based Complementary and Alternative Medicine, Volume 2011, Issue 1, 2011., 2011
Protease inhibitors (PIs) and hemagglutinins are defense proteins produced by many organisms. From Chinese mini‐black soybeans, a 17.5‐kDa PI was isolated using chromatography on Q‐Sepharose, SP‐Sepharose, and DEAE‐cellulose. A 25‐kDa hemagglutinin was purified similarly, but using Superdex 75 instead of DEAE‐cellulose in the final step.
Xiu Juan Ye, Tzi Bun Ng
wiley   +5 more sources

Safety of dried fruits of Synsepalum dulcificum as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Journal, Volume 19, Issue 6, June 2021., 2021
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on dried fruits of Synsepalum dulcificum as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is pitted and dried (by lyophilisation) fruits of S. dulcificum.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Henk van Loveren, Leonard Matijević, Helle Katrine Knutsen   +27 more
wiley   +1 more source

Publication Only

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Virtual screening and molecular dynamics simulation study of plant protease inhibitors against SARS-CoV-2 envelope protein. [PDF]

Inform Med Unlocked, 2022
Kirar M, Singh H, Sehrawat N.
europepmc   +1 more source

Insulin-Loaded Soybean Trypsin Inhibitor-Chitosan Nanoparticles: Preparation, Characterization, and Protective Effect Evaluation. [PDF]

Polymers (Basel), 2023
Zhang Y, Liu R, Feng Q, Li H, Li Y, Liu X.   +5 more
europepmc   +1 more source

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity-A Review. [PDF]

Molecules, 2023
Kolodziejczyk-Czepas J, Czepas J.
europepmc   +1 more source

Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets. [PDF]

Int J Mol Sci, 2022
Bonturi CR, Silva Teixeira AB, Rocha VM, Valente PF, Oliveira JR, Filho CMB, Fátima Correia Batista I, Oliva MLV.   +7 more
europepmc   +1 more source

Interactions between Soybean Trypsin Inhibitor and Chitosan in an Aqueous Solution. [PDF]

Polymers (Basel), 2023
Zhang Y, Liu R, Li H, Li Y, Liu X.
europepmc   +1 more source