Results 21 to 30 of about 3,879 (179)
Blood, 2005 The anionic phospholipid, phosphatidyl-L-serine (PS), is sequestered in the inner layer of the plasma membrane in normal cells. Upon injury, activation, and apoptosis, PS becomes exposed on the surfaces of cells and sheds microparticles, which are ...
Hsiu‐Hui Chen +4 more
semanticscholar +1 more source
Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases [PDF]
, 2011 Phytocystatins are inhibitors of cysteine-proteases from plants putatively involved in plant defence based on their capability of inhibit heterologous enzymes.
A Kiggundu +49 more
core +2 more sources
Rigidity analysis of HIV-1 protease [PDF]
J. Phys.: Conf. Ser. 286, 012006, (2011), 2011 We present a rigidity analysis on a large number of X-ray crystal structures of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software FIRST. We find that although the rigidity profile remains similar across a comprehensive set of high resolution structures, the profile changes significantly in the presence of an inhibitor.
arxiv +1 more source
In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19 [PDF]
, 2020 Virtual screening of phytochemicals was performed through molecular docking, simulation, in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, total 154 phytochemicals with analogous structure from limonoids and triterpenoids ...
arxiv +1 more source
COELENTERATE TOXINS, ITS PHARMACEUTICAL AND THERAPEUTIC EFFECTS [PDF]
, 2021 Present review article emphasizes species specific coelenterate toxins, its pharmaceutical and therapeutic effects. Most of the coelenterates inflict venom accidently by using nematocysts found on arms.
SHARMA, SIMRAN, UPADHYAY, RAVI KANT
core +1 more source
Benchmarking Deep Graph Generative Models for Optimizing New Drug Molecules for COVID-19 [PDF]
arXiv, 2021 Design of new drug compounds with target properties is a key area of research in generative modeling. We present a small drug molecule design pipeline based on graph-generative models and a comparison study of two state-of-the-art graph generative models for designing COVID-19 targeted drug candidates: 1) a variational autoencoder-based approach (VAE ...
arxiv
Canadian Journal of Zoology, 2019 Apple snails (Pomacea Perry, 1810) are successful invaders that cause ecological perturbations, economic losses, and medical issues. A peculiar trait of this snail is a high biological potential, related to the absence of predators of their eggs.
S. Ituarte +5 more
semanticscholar +1 more source
Sequencing and Analysis of a Miraculin Homolog from Two Ragweed Species [PDF]
, 2016 Our lab has previously isolated the gene for miraculin, a taste-modifying protein, from the pollen of Ambrosia trifida. This weedy plant, commonly known as Giant Ragweed, is a major producer of pollen that causes hay fever.
Mandzy, Kyj R
core +1 more source
THERAPEUTICS APPROACHES OF INVERTEBRATE ANIMAL TOXINS: A REVIEW [PDF]
, 2022 The present review article describes invertebrate venoms and various toxins secreted by them. Animal venoms are stores of novel peptides which exhibit a wide variety of biological effects and actively interact with pathogen and parasites.
SHARMA, SIMRAN, UPADHYAY, RAVI KANT
core +1 more source
Drug design principles from electric field calculations: understanding SARS-CoV-2 main protease interaction with X77 non-covalent inhibitor [PDF]
arXiv, 2020 Fast and effective drug discovery processes rely on rational drug design to circumvent the tedious and expensive trial and error approach. However, accurate predictions of new remedies, which are often enzyme inhibitors, require a clear understanding of the nature and function of the key players governing the interaction between the drug candidate and ...
arxiv