The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant [PDF]
, 2020 One of the most common mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene is the N34S variant which is strongly associated with chronic pancreatitis. Although it is assumed that N34S mutation constitutes a high-risk factor, the underlying pathologic mechanism is still unknown.
arxiv +1 more source
Proposing a fungal metabolite-Flaviolin as a potential inhibitor of 3CLpro of novel coronavirus SARS-CoV2 using docking and molecular dynamics [PDF]
arXiv, 2020 Here after performing docking and molecular dynamics of various small molecules derived as a secondary metabolite from fungi, we propose Flaviolin to act as potent inhibitor of 3-chymotrypsin (3C) like protease (3CLpro) of noval corona virus SARS-CoV2 responsible for pandemic condition caused by coronavirus disease 2019 (COVID-19).
arxiv
天然神経毒構造に基くランダムペプチドライブラリーの作製と分子進化工学技術の開発 [PDF]
, 2014 この博士論文は内容の要約のみ公表しています筑波大学 (University of Tsukuba ...
CAI Weiyan, 蔡 维艳(維艶)
core
Elucidating the function of mycorrhizal-induced Kunitz protease inhibitors and characterization of their putative target proteases in Medicago truncatula [PDF]
, 2014 Most terrestrial plants live in symbiosis with arbuscular mycorrhizal fungi. In this study, a mycorrhizal-induced gene family of Medicago truncatula encoding putative Kunitz protease inhibitors was functionally characterized by means of biomolecular ...
Hirsch, Stefanie S.
core +2 more sources
How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease [PDF]
, 2013 A central question is how the conformational changes of proteins affect their function and the inhibition of this function by drug molecules. Many enzymes change from an open to a closed conformation upon binding of substrate or inhibitor molecules.
arxiv +1 more source
In Silico Investigations on the Potential Inhibitors for COVID-19 Protease [PDF]
arXiv, 2020 A novel strain of coronavirus, namely, COVID-19 has been identified in Wuhan city of China in December 2019. There are no specific therapies available and investigations regarding the treatment of the COVID-19 are still lacking. This prompted us to perform a preliminary in silico study on the COVID-19 protease with anti-malarial compounds in the search
arxiv
Coronavirus SARS-CoV-2: Analysis of subgenomic mRNA transcription, 3CLpro and PL2pro protease cleavage sites and protein synthesis [PDF]
arXiv, 2020 Coronaviruses have recently caused world-wide severe outbreaks: SARS (Severe Acute Respiratory Syndrome) in 2002 and MERS (Middle-East Respiratory Syndrome) in 2012. At the end of 2019, a new coronavirus outbreak appeared in Wuhan (China) seafood market as first focus of infection, becoming a pandemics in 2020, spreading mainly into Europe and Asia ...
arxiv
, 2019 Research and Practice in Thrombosis and Haemostasis, Volume 3, Issue S1, Page 1-228, July 2019.
wiley +1 more source
Blood, 2012 Hemophilia is treated by IV replacement therapy with Factor VIII (FVIII) or Factor IX (FIX), either on demand to resolve bleeding, or as prophylaxis. Improved treatment may be provided by drugs designed for subcutaneous and less frequent administration ...
I. Hilden +18 more
semanticscholar +1 more source
Plant proteinaceous inhibitors of proteinases and alpha-amylases [PDF]
, 1987 Plant proteins which are inhibitory towards various types of enzymes from a wide range of organisms have been extensively studied for many years. Proteinas e inhibitors have received particular attention and accordingly a number of reviews concerning ...
Carbonero Zalduegui, Pilar +5 more
core +1 more source